Abstract
T LYMPHOCYTES from mice1 and healthy humans2 immunized against the human immunodeficiency virus (HIV) envelope have recently been shown to recognize two antigenic regions of the gp160 HIV-envelope protein which have been located on the basis of amphipathicity3-6. In HIV-infected humans, T-cell proliferative responses are lost soon after infection7,8. Here we demonstrate that interleukin-2 production is often retained even when proliferative activity is absent, and that it can be used to monitor T-helper cell responses by HIV-seropositive donors. We use this approach to investigate the T-helper cell response of 42 asymptomatic HIV-seropositive patients to four synthetic gp160 peptides and to influenza A virus, an antigen requiring intact CD4 T-helper cell function. As many as 67% of the HIV-seropositive donors who retain responsiveness to influenza A virus respond to a single peptide, and 85-90% responded to at least one of the peptides.
Original language | English |
---|---|
Pages (from-to) | 383-385 |
Number of pages | 3 |
Journal | Nature |
Volume | 339 |
Issue number | 6223 |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- General