During hemodialysis treatment blood interaction with foreign surfaces may result in different biological reactions, including lymphocyte stimulation. The aim of this study was to verify interleukin-2 receptor (IL-2R) production by lymphocytes of uremic patients. Nineteen hemodialyzed patients (HD), 6 non-hemodialyzed chronic uremic patients (UR) and 8 healthy control subjects (C) were included in the study. In 8 HD, 6 UR and 8 C we measured IL-2R production in the supernatant of Peripheral Blood Mononuclear Cells (PBMC) cultured for 24 hours. In HD and C we also measured IL-2R and Beta-2-M plasma levels. Results show significantly (p <0.001) higher values of IL-2R release in supernatant of PBMC isolated from HD patients as compared to UR and C, indicating a chronic T-cell activation induced by dialysis procedures. In addition, HD patients show plasma IL-2R levels significantly (p <0.001) higher than controls. Finally, a highly significant direct relationship was found, in HD patients, between IL-2R and Beta-2-M predialytic plasma concentrations (r:0.828, p <0.001) suggesting that Beta-2-M plasma levels are highly influenced by T-cell activation.
|Translated title of the contribution||Interleukin-2 receptor production by lymphocytes of uremic patients|
|Number of pages||5|
|Journal||Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia|
|Publication status||Published - 1993|
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