Interleukin-2 suppresses established long-term potentiation and inhibits its induction in the rat hippocampus

Virginia Tancredi, Cristina Zona, Francesca Velotti, Fabrizio Eusebi, Angela Santoni

Research output: Contribution to journalArticle

Abstract

The effects of recombinant interleukin-2 (rIL-2) on teh potentiation of thesynaptic transmission were studied in rat hippocampal slices by using extracellular field potential recordings. The application of rIL-2 inhibited the induction of both short-term (STP) and long-term potentiation LTP) in a dose-dependent manner. In addition, rIL-2 (1000 U/ml) reduced both post-tetanic potentiation (PTP) and LTP maintenance phase. The possible involvement of rIL-2 action on the synaptic potentiation with the enzymatic activity of protein kinase systems is discussed.

Original languageEnglish
Pages (from-to)149-151
Number of pages3
JournalBrain Research
Volume525
Issue number1
DOIs
Publication statusPublished - Aug 13 1990

Keywords

  • Hippocampal slice
  • Interleukin-2
  • Long-term potentiation

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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