Interleukin-28B genetic variants in untreated Italian HCV-infected patients: A multicentre study

Leonardo Mottola, Giovanni Cenderello, Valeria A. Piazzolla, Paolo Forte, Vito Carretta, Fabrizio Mecenate, Giuseppina Brancaccio, Rosalba Minisini, Massimo Zuin, Natalia Terreni, Monica Monti, Alberto Eraldo Colombo, Lorenzo Nosotti, Nicola Minerva, Ilaria Luzzitelli, Alba Kostandini, Giuseppe Cuccorese, Maurizio Russello, Rosanna Santoro, Alessandra Mangia

Research output: Contribution to journalArticle

Abstract

Background & Aims: Different prevalence of favourable IL28BCC genotype have been reported in studies performed in different countries around the world. Data on distribution of IL28B genotypes in healthy Italian subjects are lacking. Methods: Studies on prospectively collected untreated chronic HCV-infected Italian patients led to conflicting results. To investigate the prevalence of IL28B genotypes in untreated HCV-infected patients and in subjects able to clear HCV, and to compare them to the prevalence registered in healthy Italian controls. To evaluate IL28B prevalence across different HCV genotypes. Results: IL28BCC was observed in 30.9% of chronic HCV patients, in 71.0% of subjects able to clear HCV infection and in 41.6% of the Italian controls. The frequency of IL28BCC was higher in HCV genotype 2 and 3 than in 1 (38.3 vs. 28.2) (P = 0.02). Levels of ALT higher in IL28BCC than in non-CC were observed regardless of HCV genotypes (P = 0.0014). Conclusions: IL28BCC frequencies progressively decline from subjects with spontaneous HCV clearance to normal non-infected subjects and to chronically infected. This study suggests that patients with IL28BCC, if genotype 1, are able to clear HCV more often than if genotype 2 and 3 infected, and that CC genotype is associated with higher grade of necro-inflammation.

Original languageEnglish
Pages (from-to)482-488
Number of pages7
JournalLiver International
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Keywords

  • Genotype 1
  • Hepatitis C
  • Interleukin 28B
  • Naive
  • Related gene polymorphisms

ASJC Scopus subject areas

  • Hepatology
  • Medicine(all)

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