Interleukin-28B genetic variants in untreated Italian HCV-infected patients: A multicentre study

Leonardo Mottola, Giovanni Cenderello, Valeria A. Piazzolla, Paolo Forte, Vito Carretta, Fabrizio Mecenate, Giuseppina Brancaccio, Rosalba Minisini, Massimo Zuin, Natalia Terreni, Monica Monti, Alberto Eraldo Colombo, Lorenzo Nosotti, Nicola Minerva, Ilaria Luzzitelli, Alba Kostandini, Giuseppe Cuccorese, Maurizio Russello, Rosanna Santoro, Alessandra Mangia

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background & Aims: Different prevalence of favourable IL28BCC genotype have been reported in studies performed in different countries around the world. Data on distribution of IL28B genotypes in healthy Italian subjects are lacking. Methods: Studies on prospectively collected untreated chronic HCV-infected Italian patients led to conflicting results. To investigate the prevalence of IL28B genotypes in untreated HCV-infected patients and in subjects able to clear HCV, and to compare them to the prevalence registered in healthy Italian controls. To evaluate IL28B prevalence across different HCV genotypes. Results: IL28BCC was observed in 30.9% of chronic HCV patients, in 71.0% of subjects able to clear HCV infection and in 41.6% of the Italian controls. The frequency of IL28BCC was higher in HCV genotype 2 and 3 than in 1 (38.3 vs. 28.2) (P = 0.02). Levels of ALT higher in IL28BCC than in non-CC were observed regardless of HCV genotypes (P = 0.0014). Conclusions: IL28BCC frequencies progressively decline from subjects with spontaneous HCV clearance to normal non-infected subjects and to chronically infected. This study suggests that patients with IL28BCC, if genotype 1, are able to clear HCV more often than if genotype 2 and 3 infected, and that CC genotype is associated with higher grade of necro-inflammation.

Original languageEnglish
Pages (from-to)482-488
Number of pages7
JournalLiver International
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 1 2015

Fingerprint

Interleukins
Multicenter Studies
Genotype
Healthy Volunteers
Inflammation

Keywords

  • Genotype 1
  • Hepatitis C
  • Interleukin 28B
  • Naive
  • Related gene polymorphisms

ASJC Scopus subject areas

  • Hepatology
  • Medicine(all)

Cite this

Interleukin-28B genetic variants in untreated Italian HCV-infected patients : A multicentre study. / Mottola, Leonardo; Cenderello, Giovanni; Piazzolla, Valeria A.; Forte, Paolo; Carretta, Vito; Mecenate, Fabrizio; Brancaccio, Giuseppina; Minisini, Rosalba; Zuin, Massimo; Terreni, Natalia; Monti, Monica; Colombo, Alberto Eraldo; Nosotti, Lorenzo; Minerva, Nicola; Luzzitelli, Ilaria; Kostandini, Alba; Cuccorese, Giuseppe; Russello, Maurizio; Santoro, Rosanna; Mangia, Alessandra.

In: Liver International, Vol. 35, No. 2, 01.02.2015, p. 482-488.

Research output: Contribution to journalArticle

Mottola, L, Cenderello, G, Piazzolla, VA, Forte, P, Carretta, V, Mecenate, F, Brancaccio, G, Minisini, R, Zuin, M, Terreni, N, Monti, M, Colombo, AE, Nosotti, L, Minerva, N, Luzzitelli, I, Kostandini, A, Cuccorese, G, Russello, M, Santoro, R & Mangia, A 2015, 'Interleukin-28B genetic variants in untreated Italian HCV-infected patients: A multicentre study', Liver International, vol. 35, no. 2, pp. 482-488. https://doi.org/10.1111/liv.12630
Mottola, Leonardo ; Cenderello, Giovanni ; Piazzolla, Valeria A. ; Forte, Paolo ; Carretta, Vito ; Mecenate, Fabrizio ; Brancaccio, Giuseppina ; Minisini, Rosalba ; Zuin, Massimo ; Terreni, Natalia ; Monti, Monica ; Colombo, Alberto Eraldo ; Nosotti, Lorenzo ; Minerva, Nicola ; Luzzitelli, Ilaria ; Kostandini, Alba ; Cuccorese, Giuseppe ; Russello, Maurizio ; Santoro, Rosanna ; Mangia, Alessandra. / Interleukin-28B genetic variants in untreated Italian HCV-infected patients : A multicentre study. In: Liver International. 2015 ; Vol. 35, No. 2. pp. 482-488.
@article{837963384c9e4ce9b1b643b99e7c8aee,
title = "Interleukin-28B genetic variants in untreated Italian HCV-infected patients: A multicentre study",
abstract = "Background & Aims: Different prevalence of favourable IL28BCC genotype have been reported in studies performed in different countries around the world. Data on distribution of IL28B genotypes in healthy Italian subjects are lacking. Methods: Studies on prospectively collected untreated chronic HCV-infected Italian patients led to conflicting results. To investigate the prevalence of IL28B genotypes in untreated HCV-infected patients and in subjects able to clear HCV, and to compare them to the prevalence registered in healthy Italian controls. To evaluate IL28B prevalence across different HCV genotypes. Results: IL28BCC was observed in 30.9{\%} of chronic HCV patients, in 71.0{\%} of subjects able to clear HCV infection and in 41.6{\%} of the Italian controls. The frequency of IL28BCC was higher in HCV genotype 2 and 3 than in 1 (38.3 vs. 28.2) (P = 0.02). Levels of ALT higher in IL28BCC than in non-CC were observed regardless of HCV genotypes (P = 0.0014). Conclusions: IL28BCC frequencies progressively decline from subjects with spontaneous HCV clearance to normal non-infected subjects and to chronically infected. This study suggests that patients with IL28BCC, if genotype 1, are able to clear HCV more often than if genotype 2 and 3 infected, and that CC genotype is associated with higher grade of necro-inflammation.",
keywords = "Genotype 1, Hepatitis C, Interleukin 28B, Naive, Related gene polymorphisms",
author = "Leonardo Mottola and Giovanni Cenderello and Piazzolla, {Valeria A.} and Paolo Forte and Vito Carretta and Fabrizio Mecenate and Giuseppina Brancaccio and Rosalba Minisini and Massimo Zuin and Natalia Terreni and Monica Monti and Colombo, {Alberto Eraldo} and Lorenzo Nosotti and Nicola Minerva and Ilaria Luzzitelli and Alba Kostandini and Giuseppe Cuccorese and Maurizio Russello and Rosanna Santoro and Alessandra Mangia",
year = "2015",
month = "2",
day = "1",
doi = "10.1111/liv.12630",
language = "English",
volume = "35",
pages = "482--488",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "2",

}

TY - JOUR

T1 - Interleukin-28B genetic variants in untreated Italian HCV-infected patients

T2 - A multicentre study

AU - Mottola, Leonardo

AU - Cenderello, Giovanni

AU - Piazzolla, Valeria A.

AU - Forte, Paolo

AU - Carretta, Vito

AU - Mecenate, Fabrizio

AU - Brancaccio, Giuseppina

AU - Minisini, Rosalba

AU - Zuin, Massimo

AU - Terreni, Natalia

AU - Monti, Monica

AU - Colombo, Alberto Eraldo

AU - Nosotti, Lorenzo

AU - Minerva, Nicola

AU - Luzzitelli, Ilaria

AU - Kostandini, Alba

AU - Cuccorese, Giuseppe

AU - Russello, Maurizio

AU - Santoro, Rosanna

AU - Mangia, Alessandra

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Background & Aims: Different prevalence of favourable IL28BCC genotype have been reported in studies performed in different countries around the world. Data on distribution of IL28B genotypes in healthy Italian subjects are lacking. Methods: Studies on prospectively collected untreated chronic HCV-infected Italian patients led to conflicting results. To investigate the prevalence of IL28B genotypes in untreated HCV-infected patients and in subjects able to clear HCV, and to compare them to the prevalence registered in healthy Italian controls. To evaluate IL28B prevalence across different HCV genotypes. Results: IL28BCC was observed in 30.9% of chronic HCV patients, in 71.0% of subjects able to clear HCV infection and in 41.6% of the Italian controls. The frequency of IL28BCC was higher in HCV genotype 2 and 3 than in 1 (38.3 vs. 28.2) (P = 0.02). Levels of ALT higher in IL28BCC than in non-CC were observed regardless of HCV genotypes (P = 0.0014). Conclusions: IL28BCC frequencies progressively decline from subjects with spontaneous HCV clearance to normal non-infected subjects and to chronically infected. This study suggests that patients with IL28BCC, if genotype 1, are able to clear HCV more often than if genotype 2 and 3 infected, and that CC genotype is associated with higher grade of necro-inflammation.

AB - Background & Aims: Different prevalence of favourable IL28BCC genotype have been reported in studies performed in different countries around the world. Data on distribution of IL28B genotypes in healthy Italian subjects are lacking. Methods: Studies on prospectively collected untreated chronic HCV-infected Italian patients led to conflicting results. To investigate the prevalence of IL28B genotypes in untreated HCV-infected patients and in subjects able to clear HCV, and to compare them to the prevalence registered in healthy Italian controls. To evaluate IL28B prevalence across different HCV genotypes. Results: IL28BCC was observed in 30.9% of chronic HCV patients, in 71.0% of subjects able to clear HCV infection and in 41.6% of the Italian controls. The frequency of IL28BCC was higher in HCV genotype 2 and 3 than in 1 (38.3 vs. 28.2) (P = 0.02). Levels of ALT higher in IL28BCC than in non-CC were observed regardless of HCV genotypes (P = 0.0014). Conclusions: IL28BCC frequencies progressively decline from subjects with spontaneous HCV clearance to normal non-infected subjects and to chronically infected. This study suggests that patients with IL28BCC, if genotype 1, are able to clear HCV more often than if genotype 2 and 3 infected, and that CC genotype is associated with higher grade of necro-inflammation.

KW - Genotype 1

KW - Hepatitis C

KW - Interleukin 28B

KW - Naive

KW - Related gene polymorphisms

UR - http://www.scopus.com/inward/record.url?scp=84921469628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921469628&partnerID=8YFLogxK

U2 - 10.1111/liv.12630

DO - 10.1111/liv.12630

M3 - Article

C2 - 25039676

AN - SCOPUS:84921469628

VL - 35

SP - 482

EP - 488

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 2

ER -