Interleukin 28B polymorphisms as predictor of response in hepatitis C virus genotype 2 and 3 infected patients

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Abstract

Single nucleotide polymorphisms near the interleukin 28B (I L-28B) gene have been identified as strong predictors of both spontaneous or Peg-interferon (Peg-IFN) and ribavirin (RBV) induced clearance of hepatitis C virus (HCV). Several studies have shown that, in patients with genotype 1 (GT-1), rs12979860 C/C and rs8099917 T/T substitutions are associated with a more than twofold increase in sustained virological response rate to Peg-IFN and RBV treatment. Although new treatment regimens based on combination of DAA with or without IFN are in the approval phase, until combination regimens with a backbone of Peg-IFN will be used, we can expect that IL28B holds its importance. The clinical relevance of IL28B genotyping in treatment of patients infected with HCV genotype 2 (GT-2) and 3 (GT-3) remains controversial. Therefore, after a careful examination of the available literature, we analyzed the impact of IL28B in GT-2 and -3. Simple size of the studies and GT-2 and GT-3 proportion were discussed. An algorithm for the practical use of IL28B in these patients was suggested at the aim of optimizing treatment.

Original languageEnglish
Pages (from-to)8924-8928
Number of pages5
JournalWorld Journal of Gastroenterology
Volume19
Issue number47
DOIs
Publication statusPublished - Dec 21 2013

Keywords

  • Genotype 3
  • Hepatitis C virus
  • Interleukin 28B
  • Liver cirrhosis

ASJC Scopus subject areas

  • Gastroenterology

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