Interleukin-6 and corticotrophin-releasing hormone mRNA are modulated during differentiation of human neuroblastoma cells

A. Stephanou, G. Melino, R. A. Knight, M. Annicchiarico-Petruzzelli, N. J. Sarlis, A. Finazzi-Agro', S. L. Lightman

Research output: Contribution to journalArticle

Abstract

Two cell clones [BE(2)-C and BE(2)-M17] derived from the human neuroblastoma cell line SK-N-BE(2) express corticotrophin-releasing hormone as well as interleukin-6 mRNA. Both genes are overexpressed, although with a different time course, following exposure to 5 μM retinoic acid, in parallel to the induction of neuroblastic differentiation. On the contrary, we are unable to detect interleukin-1β mRNA in these cell lines. Both cytokines are known to neuroblastoma cells indicate a complex dialogue between tumour cells and anti-tumour immunity.

Original languageEnglish
Pages (from-to)45-49
Number of pages5
JournalNeuropeptides
Volume23
Issue number1
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Clinical Neurology
  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

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