Two cell clones [BE(2)-C and BE(2)-M17] derived from the human neuroblastoma cell line SK-N-BE(2) express corticotrophin-releasing hormone as well as interleukin-6 mRNA. Both genes are overexpressed, although with a different time course, following exposure to 5 μM retinoic acid, in parallel to the induction of neuroblastic differentiation. On the contrary, we are unable to detect interleukin-1β mRNA in these cell lines. Both cytokines are known to neuroblastoma cells indicate a complex dialogue between tumour cells and anti-tumour immunity.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Neurology
- Cellular and Molecular Neuroscience