Interleukin-6 and soluble intercellular adhesion molecule-1 in renal cancer patients and cultured renal cancer cells

Daniela Favaro, Manuela Santarosa, Michele Quaia, Enzo Galligioni

Research output: Contribution to journalArticlepeer-review

Abstract

Serum interleukin-6 (IL-6) and soluble intercellular adhesion molecule- 1 (sICAM-1) levels were measured by enzyme-linked immunosorbent assay in 62 renal cancer patients: 30 were tumor-free after radical nephrectomy and 32 presented with metastatic disease. Serum IL-6 was undetectable in all but one of the tumor-free patients, whereas 41% (13 of 32) of the metastatic patients presented serum IL-6 levels. Furthermore, there was a significant correlation between serum IL-6 levels and a shorter overall survival (p = 0.009). Moreover, serum sICAM-1 levels were significantly higher (p = 0.05) in the metastatic patients with detectable serum IL-6 than in those without IL-6, suggesting a possible link between IL-6 and sICAM-1. The probability of a shorter overall survival was greater in the metastatic patients with both serum IL-6 and elevated sICAM-1 levels (>635 ng/ml), than in those with elevated sICAM-1 but without IL-6 (p = 0.01). The production. of IL-6 by 16 freshly dissociated renal cancer cells cultured in vitro was also observed. It appeared that IL-6 levels did not correlate with the expression and release of ICAM-1 by cultured cells, although the highest values of ICAM-1 release were found in cultures synthesizing the highest values of IL-6. In conclusion, in vivo presence of serum IL-6 and elevated sICAM-1 levels is related to an unfavorable prognosis; it can be speculated that the cells capable of releasing high levels of sICAM-1 and IL-6 may negatively influence the antitumor response.

Original languageEnglish
Pages (from-to)51-58
Number of pages8
JournalUrologic Oncology: Seminars and Original Investigations
Volume3
Issue number2
DOIs
Publication statusPublished - Mar 1997

Keywords

  • Cultured cells
  • Interleukin-6 soluble intercellular adhesion molecule-1 (ICAM-1)
  • Renal cell carcinoma
  • Serum levels

ASJC Scopus subject areas

  • Oncology
  • Urology

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