Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain

Federico Licastro, Luigi Maria Edoardo Grimaldi, Massimiliano Bonafè, Chiappelli Martina, Fabiola Olivieri, Luca Cavallone, Simona Giovanietti, Eliezer Masliah, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

Two different polymorphic regions of the interleukin-6 (IL-6) gene were investigated in patients with Alzheimer's disease (AD) and non-demented controls. The -174 C allele in the promoter region of IL-6 gene was over-represented in AD patients compared to controls and significantly increased the risk of AD. Moreover, the -174 CC genotype was associated with a high risk of the disease in women. The D allele of a variable number of tandem repeat (VNTR) was in strong linkage disequilibrium with the -174 C allele and slightly increased AD risk. On the other hand, the frequency of the VNTR C allele was decreased in patients with AD and was negatively associated with the risk of developing AD. Both the -174 CC and VNTR DD genotypes were also associated with increased IL-6 levels in the blood and brain from AD. These findings suggest that IL-6 may play a multifaceted role in AD by affecting the turnover of the cytokine.

Original languageEnglish
Pages (from-to)921-926
Number of pages6
JournalNeurobiology of Aging
Volume24
Issue number7
DOIs
Publication statusPublished - Nov 2003

Keywords

  • Alzheimer's disease risk
  • Blood and brain IL-6 levels
  • IL-6 gene

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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