Interleukin-6 gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae

Marina Sironi, Antonio Sica, Franca Riganti, Luciano Licciardello, Francesco Colotta, Alberto Mantovani

Research output: Contribution to journalArticle

Abstract

The present study was designed to investigate the effect of membrane proteoglycans (MPG) from Klebsiella pneumoniae on IL-6 production by human peripheral blood monocytes. Exposure in vitro to MPG induced release of IL-6 activity from human monocytes, as assessed by the 7TD1 hybridoma assay. MPG-induced hybridoma growth factor activity was blocked by anti-IL-6 antibodies. MPG induced expression in human monocytes of IL-6 mRNA transcripts as assessed by Northern blot analysis. Induction of IL-6 in mononuclear phagocytes may play a role in the immunomodulatory activity of MPG.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalInternational Journal of Immunopharmacology
Volume12
Issue number4
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Fingerprint Dive into the research topics of 'Interleukin-6 gene expression and production induced in human monocytes by membrane proteoglycans from Klebsiella pneumoniae'. Together they form a unique fingerprint.

  • Cite this