Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor α by transcriptional and post-transcriptional mechanisms

Guido Poli, Peter Bressler, Audrey Kinter, Elia Duh, William C. Timmer, Arnold Rabson, J. Shawn Justement, Sharilyn Stanley, Anthony S. Fauci

Research output: Contribution to journalArticlepeer-review

Abstract

The immunoregulatory cytokine interleukin 6 (IL-6) directly upregulates production of human immunodeficiency virus (HIV) in acutely as well as in chronically infected cells of monocytic lineage. In addition, IL-6 synergizes with tumor necrosis factor α (TNF-α) in the induction of latent HIV expression. Unlike TNF-α, upregulation of viral expression induced by IL-6 alone does not occur at the transcriptional level and it is not associated with accumulation of HIV RNA. However, when IL-6 and TNF-α synergistically stimulate HIV production, accumulation of HIV RNA and increased transcription are observed, indicating that IL-6 affects HIV expression at multiple (transcriptional and post-transcriptional) levels.

Original languageEnglish
Pages (from-to)151-158
Number of pages8
JournalJournal of Experimental Medicine
Volume172
Issue number1
Publication statusPublished - Jul 1 1990

ASJC Scopus subject areas

  • Immunology

Fingerprint

Dive into the research topics of 'Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor α by transcriptional and post-transcriptional mechanisms'. Together they form a unique fingerprint.

Cite this