Abstract
The central endogenous opioid system is involved in the modulation of interleukin (IL)-6, an inflammatory cytokine that plays a major role in the acute phase response. The present study evaluates whether specific opioid receptor subtypes are selectively involved in this immnunomodulatory action. IL-1β was administered either intracerebroventricularly or intraperitoneally at the dose of 400 ng to rats pretreated with the μ-antagonist β- funaltrexamine, the δ-antagonist naltrindole, or the κ-antagonist nor- binaltorphimine, each at the doses of 1, 10, and 100 μg/rat intracerebroventricularly. Serum IL-6 levels were measured 2 h later. The results show that μ-receptor blockade increases, whereas δ-receptor blockade decreases IL-6 induction, suggesting that the fine tuning exerted by opioids on the immune system may be achieved through a balance of opposing effects. Moreover the three antagonists affect IL-6 induction by central and peripheral IL-1β with a similar pattern, indicating that the brain endogenous opioid system plays a general role in the regulation of this cytokine.
| Original language | English |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 273 |
| Issue number | 3 42-3 |
| Publication status | Published - 1997 |
Fingerprint
Keywords
- β-funaltrexamine
- Immunomodulation
- Interleukin-1
- Naltrindole
- Nor- binaltorphimine
ASJC Scopus subject areas
- Physiology
- Physiology (medical)
Cite this
Interleukin-6 is differently modulated by central opioid receptor subtypes. / Bertolucci, Magali; Perego, Carlo; De Simoni, Maria Grazia.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 273, No. 3 42-3, 1997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interleukin-6 is differently modulated by central opioid receptor subtypes
AU - Bertolucci, Magali
AU - Perego, Carlo
AU - De Simoni, Maria Grazia
PY - 1997
Y1 - 1997
N2 - The central endogenous opioid system is involved in the modulation of interleukin (IL)-6, an inflammatory cytokine that plays a major role in the acute phase response. The present study evaluates whether specific opioid receptor subtypes are selectively involved in this immnunomodulatory action. IL-1β was administered either intracerebroventricularly or intraperitoneally at the dose of 400 ng to rats pretreated with the μ-antagonist β- funaltrexamine, the δ-antagonist naltrindole, or the κ-antagonist nor- binaltorphimine, each at the doses of 1, 10, and 100 μg/rat intracerebroventricularly. Serum IL-6 levels were measured 2 h later. The results show that μ-receptor blockade increases, whereas δ-receptor blockade decreases IL-6 induction, suggesting that the fine tuning exerted by opioids on the immune system may be achieved through a balance of opposing effects. Moreover the three antagonists affect IL-6 induction by central and peripheral IL-1β with a similar pattern, indicating that the brain endogenous opioid system plays a general role in the regulation of this cytokine.
AB - The central endogenous opioid system is involved in the modulation of interleukin (IL)-6, an inflammatory cytokine that plays a major role in the acute phase response. The present study evaluates whether specific opioid receptor subtypes are selectively involved in this immnunomodulatory action. IL-1β was administered either intracerebroventricularly or intraperitoneally at the dose of 400 ng to rats pretreated with the μ-antagonist β- funaltrexamine, the δ-antagonist naltrindole, or the κ-antagonist nor- binaltorphimine, each at the doses of 1, 10, and 100 μg/rat intracerebroventricularly. Serum IL-6 levels were measured 2 h later. The results show that μ-receptor blockade increases, whereas δ-receptor blockade decreases IL-6 induction, suggesting that the fine tuning exerted by opioids on the immune system may be achieved through a balance of opposing effects. Moreover the three antagonists affect IL-6 induction by central and peripheral IL-1β with a similar pattern, indicating that the brain endogenous opioid system plays a general role in the regulation of this cytokine.
KW - β-funaltrexamine
KW - Immunomodulation
KW - Interleukin-1
KW - Naltrindole
KW - Nor- binaltorphimine
UR - http://www.scopus.com/inward/record.url?scp=0030881482&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030881482&partnerID=8YFLogxK
M3 - Article
VL - 273
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 3 42-3
ER -