Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas

M. Páez Pereda, P. Lohrer, D. Kovalovsky, C. Perez Castro, V. Goldberg, M. Losa, A. Chervín, S. Berner, H. Molina, G. K. Stalla, U. Renner, E. Arzt

Research output: Contribution to journalArticle

Abstract

Interleukins and their receptors are expressed intrinsically in the anterior pituitary and regulate hormone production and cell proliferation. It has previously been shown that interleukin-6 (IL-6) regulates hormone secretion in normal pituitary cells and cell lines. Here we examined the effects of IL-6 on propiomelanocortin (POMC) expression and ACTH production in corticotroph adenoma cells in vitro. We found that IL-6 stimulates both ACTH secretion and POMC gene expression in corticotroph adenoma cell cultures. This first demonstration of the stimulatory action of IL-6 on human corticotroph adenoma cell function provides further evidence for a direct action of IL-6 on corticotroph pituitary cells. We have confirmed previous reports of IL-6 production by corticotroph adenoma cells and in addition, demonstrated for the first time that the synthetic glucocorticoid dexamethasone is a potent suppressor of intratumoral IL-6 production. This intratumoral produced IL-6 may be in part responsible, in an autocrine manner, for the stimulation of ACTH synthesis and secretion. Our results suggest that IL-6 might play a role in the pathogenesis of Cushing's disease. However, elevated glucocorticoid levels in patients with Cushing's disease may prevent excessive action of IL-6 on ACTH production and tumor progression of corticotroph adenomas in vivo.

Original languageEnglish
Pages (from-to)202-207
Number of pages6
JournalExperimental and Clinical Endocrinology and Diabetes
Volume108
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • ACTH
  • Corticotroph adenoma
  • Interleukin-6
  • Proopiomelanocortin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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    Páez Pereda, M., Lohrer, P., Kovalovsky, D., Perez Castro, C., Goldberg, V., Losa, M., Chervín, A., Berner, S., Molina, H., Stalla, G. K., Renner, U., & Arzt, E. (2000). Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas. Experimental and Clinical Endocrinology and Diabetes, 108(3), 202-207. https://doi.org/10.1055/s-2000-7887