TY - JOUR
T1 - Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism
AU - Albani, Diego
AU - Batelli, Sara
AU - Polito, Letizia
AU - Prato, Francesca
AU - Pesaresi, Marzia
AU - Gajo, Giovanni Battista
AU - De Angeli, Sergio
AU - Zanardo, Andrea
AU - Galimberti, Daniela
AU - Scarpini, Elio
AU - Gallucci, Maurizio
AU - Forloni, Gianluigi
PY - 2009/6
Y1 - 2009/6
N2 - The transcription rate of interleukin-6 (IL-6) can be reduced by the C-allele of a polymorphism (rs1800795) located in the 5-flanking region of the IL-6 gene (NM-000600), and IL-6 plasma levels increase with age. We assembled an elderly Italian population ["The Treviso Longeva (Trelong) study", age range 70-106 years, n = 668 subjects] and assessed rs1800795 genotype and plasma IL-6 concentrations. The rs1800795 genotype was also assessed in an independent Italian study ("Milan" study, age range 70-96, n∈=∈245 subjects). To verify an age- or sex-specific effect of rs1800795 genotype we compared people younger (70-85) and older (85+) than 85 years of age. We found a significant reduction in the frequency of rs1800795 C/C genotype in 85+ men from the Trelong study, while in the Milan study this data did not reach significance. However, considering the two studies together, the frequency of the rs1800795 C/C genotype was significantly lower in 85+ than in 70-85 males (4.0% and 10.7%, respectively), while it remained unchanged in females. As for IL-6 plasma levels, after a multivariate analysis to control for confounders, a correlation between age and plasma IL-6 concentrations was revealed (P∈
AB - The transcription rate of interleukin-6 (IL-6) can be reduced by the C-allele of a polymorphism (rs1800795) located in the 5-flanking region of the IL-6 gene (NM-000600), and IL-6 plasma levels increase with age. We assembled an elderly Italian population ["The Treviso Longeva (Trelong) study", age range 70-106 years, n = 668 subjects] and assessed rs1800795 genotype and plasma IL-6 concentrations. The rs1800795 genotype was also assessed in an independent Italian study ("Milan" study, age range 70-96, n∈=∈245 subjects). To verify an age- or sex-specific effect of rs1800795 genotype we compared people younger (70-85) and older (85+) than 85 years of age. We found a significant reduction in the frequency of rs1800795 C/C genotype in 85+ men from the Trelong study, while in the Milan study this data did not reach significance. However, considering the two studies together, the frequency of the rs1800795 C/C genotype was significantly lower in 85+ than in 70-85 males (4.0% and 10.7%, respectively), while it remained unchanged in females. As for IL-6 plasma levels, after a multivariate analysis to control for confounders, a correlation between age and plasma IL-6 concentrations was revealed (P∈
KW - IL-6
KW - Immunosenescence
KW - Inflammation
KW - Longevity
KW - Rs1800795
KW - Sex
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U2 - 10.1007/s11357-009-9092-5
DO - 10.1007/s11357-009-9092-5
M3 - Article
C2 - 19377912
AN - SCOPUS:67349247500
VL - 31
SP - 155
EP - 162
JO - Age
JF - Age
SN - 0161-9152
IS - 2
ER -