Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism

Diego Albani, Sara Batelli, Letizia Polito, Francesca Prato, Marzia Pesaresi, Giovanni Battista Gajo, Sergio De Angeli, Andrea Zanardo, Daniela Galimberti, Elio Scarpini, Maurizio Gallucci, Gianluigi Forloni

Research output: Contribution to journalArticlepeer-review

Abstract

The transcription rate of interleukin-6 (IL-6) can be reduced by the C-allele of a polymorphism (rs1800795) located in the 5-flanking region of the IL-6 gene (NM-000600), and IL-6 plasma levels increase with age. We assembled an elderly Italian population ["The Treviso Longeva (Trelong) study", age range 70-106 years, n = 668 subjects] and assessed rs1800795 genotype and plasma IL-6 concentrations. The rs1800795 genotype was also assessed in an independent Italian study ("Milan" study, age range 70-96, n∈=∈245 subjects). To verify an age- or sex-specific effect of rs1800795 genotype we compared people younger (70-85) and older (85+) than 85 years of age. We found a significant reduction in the frequency of rs1800795 C/C genotype in 85+ men from the Trelong study, while in the Milan study this data did not reach significance. However, considering the two studies together, the frequency of the rs1800795 C/C genotype was significantly lower in 85+ than in 70-85 males (4.0% and 10.7%, respectively), while it remained unchanged in females. As for IL-6 plasma levels, after a multivariate analysis to control for confounders, a correlation between age and plasma IL-6 concentrations was revealed (P∈

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalAge
Volume31
Issue number2
DOIs
Publication statusPublished - Jun 2009

Keywords

  • IL-6
  • Immunosenescence
  • Inflammation
  • Longevity
  • Rs1800795
  • Sex

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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