Interleukin-6 polymorphisms in HCC patients chronically infected with HCV

Faisal Adnan, Najeeb Ullah Khan, Aqib Iqbal, Ijaz Ali, Arnolfo Petruzziello, Rocco Sabatino, Annunziata Guzzo, Giovanna Loquercio, Gerardo Botti, Sanaullah Khan, Muhammad Naeem, Muhammad Ismail Khan

Research output: Contribution to journalArticle

Abstract

Hepatocellular carcinoma is a primary liver malignancy in which the risk of development is always multifunctional. Interleukin-6 is a proinflammatory and multifunctional cytokine, which plays an important role in the immune response, haematopoiesis and defence against viral infection. We aimed to evaluate the frequency of Interleukin-6 mutations (rs2069837 and rs17147230) associated with genetic risk of hepatocellular carcinoma in Khyber Pakthunkhwa population. A total of 72 hepatocellular carcinoma cases and 38 controls were included in this study. The genomic DNA was extracted from the peripheral blood cells and Interleukin-6 genotyping was performed using T-ARMS-PCR technique. Our results show a significant increase risk of developing hepatocellular carcinoma with the mutation within Interleukin-6 gene with heterozygous G allele (rs2069837) (OR = 10.667, 95%CI = 3.923-29.001, p = < 0.0001) and heterozygous T allele (rs17147230) (OR = 75.385, 95%CI = 9.797-580.065, p = < 0.0001). However, under recessive gene model the results were insignificant in case of Interleukin-6 rs2069837 (OR = 0.605, 95%CI = 0.217-1.689, p = 0.337), while significant in case of Interleukin-6 rs17147230 (OR = 0.298, 95%CI = 0.121-0.734, p = 0.0085). In conclusion, Interleukin-6 mutation is associated with hepatocellular carcinoma susceptibility. More related studies with other associated interleukins and their whole gene sequencing will be required.

Original languageEnglish
Article number21
JournalInfectious Agents and Cancer
Volume15
Issue number1
DOIs
Publication statusPublished - Apr 1 2020

Keywords

  • HCC
  • Interleukin-6
  • Risk factors
  • SNP

ASJC Scopus subject areas

  • Epidemiology
  • Oncology
  • Infectious Diseases
  • Cancer Research

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    Adnan, F., Khan, N. U., Iqbal, A., Ali, I., Petruzziello, A., Sabatino, R., Guzzo, A., Loquercio, G., Botti, G., Khan, S., Naeem, M., & Khan, M. I. (2020). Interleukin-6 polymorphisms in HCC patients chronically infected with HCV. Infectious Agents and Cancer, 15(1), [21]. https://doi.org/10.1186/s13027-020-00285-9