Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture

C. Zoja; A. Benigni; G. Piccinini; M. Figliuzzi; L. Longaretti; G. Remuzzi

doi:10.1155/S0962935193000614

Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture

C. Zoja, A. Benigni, G. Piccinini, M. Figliuzzi, L. Longaretti, G. Remuzzi

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.

Original language	English
Pages (from-to)	429-433
Number of pages	5
Journal	Mediators of Inflammation
Volume	2
Issue number	6
DOIs	https://doi.org/10.1155/S0962935193000614
Publication status	Published - 1993

Keywords

Extracellular matrix
Gene expression
Interleukin-6
Mesangial cells

ASJC Scopus subject areas

Immunology
Cell Biology

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title = "Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture",

abstract = "The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.",

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author = "C. Zoja and A. Benigni and G. Piccinini and M. Figliuzzi and L. Longaretti and G. Remuzzi",

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T1 - Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture

AU - Zoja, C.

AU - Benigni, A.

AU - Piccinini, G.

AU - Figliuzzi, M.

AU - Longaretti, L.

AU - Remuzzi, G.

PY - 1993

Y1 - 1993

N2 - The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.

AB - The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.

KW - Extracellular matrix

KW - Gene expression

KW - Interleukin-6

KW - Mesangial cells

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