Abstract
The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.
Original language | English |
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Pages (from-to) | 429-433 |
Number of pages | 5 |
Journal | Mediators of Inflammation |
Volume | 2 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1993 |
Keywords
- Extracellular matrix
- Gene expression
- Interleukin-6
- Mesangial cells
ASJC Scopus subject areas
- Immunology
- Cell Biology