Interleukin-6 stimulates gene expression of extracellular matrix components in bovine mesangial cells in culture

C. Zoja, A. Benigni, G. Piccinini, M. Figliuzzi, L. Longaretti, G. Remuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of interleukin-6 (IL-6) on gene expression of extracellular matrix components in bovine mesangial cells in culture has been investigated. IL-6 (100 U/ml) time dependently increased the steady state expression of mRNAs coding for α1 collagen III and fibronectin, both transcripts being 1.5- and 2.5-fold higher than basal level at 24 and 48 h, respectively. In contrast, IL-6 stimulated laminin mRNA expression only after 48 h incubation (2.5-fold upon basal level). These results suggest that IL-6 could favour glomerular matrix accumulation thus contributing to the development of glomerulosclerosis.

Original languageEnglish
Pages (from-to)429-433
Number of pages5
JournalMediators of Inflammation
Volume2
Issue number6
DOIs
Publication statusPublished - 1993

Keywords

  • Extracellular matrix
  • Gene expression
  • Interleukin-6
  • Mesangial cells

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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