Interleukin-8 is associated with acute and persistent dysfunction after optic neuritis

S. Rossi, C. Motta, V. Studer, C. Rocchi, G. Macchiarulo, F. Barbieri, G. A. Marfia, R. Furlan, G. Martino, R. Mancino, D. Centonze

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Acute optic neuritis is often in association with multiple sclerosis (MS). Proinflammatory cytokines trigger neuronal damage in neuroinflammatory disorders but their role in optic neuritis is poorly investigated. Objective: The objective of this work is to investigate the associations of intrathecal contents of proinflammatory cytokines with transient and persistent dysfunctions after optic neuritis. Methods: In 50 MS patients followed for up to six months, cerebrospinal fluid (CSF) levels of IL-1β, TNF and IL-8 were determined, along with clinical, neurophysiological and morphological measures of optic neuritis severity. Results: Visual impairment, measured by high- and low-contrast visual acuity, and delayed visual-evoked potential (VEP) latencies were significantly correlated to IL-8 levels during optic neuritis. IL-8 at the time of optic neuritis was also associated with persistent demyelination and final axonal loss, inferred by VEP and optical coherence tomography measures, respectively. Contents of IL-8 were correlated to functional visual outcomes, being higher among patients with incomplete recovery. Multivariate analysis confirmed that IL-8 significantly predicted final visual acuity, at equal values of demographics and baseline visual scores. Conclusion: Our study points to IL-8 as the main inflammatory cytokine associated with demyelination and secondary neurodegeneration in the optic nerve after optic neuritis.

Original languageEnglish
Pages (from-to)1841-1850
Number of pages10
JournalMultiple Sclerosis Journal
Volume20
Issue number14
DOIs
Publication statusPublished - Dec 16 2014

Fingerprint

Optic Neuritis
Interleukin-8
Visual Evoked Potentials
Demyelinating Diseases
Cytokines
Visual Acuity
Multiple Sclerosis
Vision Disorders
Optical Coherence Tomography
Optic Nerve
Interleukin-1
Cerebrospinal Fluid
Multivariate Analysis
Demography

Keywords

  • Cerebrospinal fluid
  • IL-8
  • inflammation
  • multiple sclerosis
  • OCT
  • visual-evoked potentials

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Interleukin-8 is associated with acute and persistent dysfunction after optic neuritis. / Rossi, S.; Motta, C.; Studer, V.; Rocchi, C.; Macchiarulo, G.; Barbieri, F.; Marfia, G. A.; Furlan, R.; Martino, G.; Mancino, R.; Centonze, D.

In: Multiple Sclerosis Journal, Vol. 20, No. 14, 16.12.2014, p. 1841-1850.

Research output: Contribution to journalArticle

Rossi, S. ; Motta, C. ; Studer, V. ; Rocchi, C. ; Macchiarulo, G. ; Barbieri, F. ; Marfia, G. A. ; Furlan, R. ; Martino, G. ; Mancino, R. ; Centonze, D. / Interleukin-8 is associated with acute and persistent dysfunction after optic neuritis. In: Multiple Sclerosis Journal. 2014 ; Vol. 20, No. 14. pp. 1841-1850.
@article{15c8ef1a8e194dd0989e5bd5e251d132,
title = "Interleukin-8 is associated with acute and persistent dysfunction after optic neuritis",
abstract = "Background: Acute optic neuritis is often in association with multiple sclerosis (MS). Proinflammatory cytokines trigger neuronal damage in neuroinflammatory disorders but their role in optic neuritis is poorly investigated. Objective: The objective of this work is to investigate the associations of intrathecal contents of proinflammatory cytokines with transient and persistent dysfunctions after optic neuritis. Methods: In 50 MS patients followed for up to six months, cerebrospinal fluid (CSF) levels of IL-1β, TNF and IL-8 were determined, along with clinical, neurophysiological and morphological measures of optic neuritis severity. Results: Visual impairment, measured by high- and low-contrast visual acuity, and delayed visual-evoked potential (VEP) latencies were significantly correlated to IL-8 levels during optic neuritis. IL-8 at the time of optic neuritis was also associated with persistent demyelination and final axonal loss, inferred by VEP and optical coherence tomography measures, respectively. Contents of IL-8 were correlated to functional visual outcomes, being higher among patients with incomplete recovery. Multivariate analysis confirmed that IL-8 significantly predicted final visual acuity, at equal values of demographics and baseline visual scores. Conclusion: Our study points to IL-8 as the main inflammatory cytokine associated with demyelination and secondary neurodegeneration in the optic nerve after optic neuritis.",
keywords = "Cerebrospinal fluid, IL-8, inflammation, multiple sclerosis, OCT, visual-evoked potentials",
author = "S. Rossi and C. Motta and V. Studer and C. Rocchi and G. Macchiarulo and F. Barbieri and Marfia, {G. A.} and R. Furlan and G. Martino and R. Mancino and D. Centonze",
year = "2014",
month = "12",
day = "16",
doi = "10.1177/1352458514537365",
language = "English",
volume = "20",
pages = "1841--1850",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "14",

}

TY - JOUR

T1 - Interleukin-8 is associated with acute and persistent dysfunction after optic neuritis

AU - Rossi, S.

AU - Motta, C.

AU - Studer, V.

AU - Rocchi, C.

AU - Macchiarulo, G.

AU - Barbieri, F.

AU - Marfia, G. A.

AU - Furlan, R.

AU - Martino, G.

AU - Mancino, R.

AU - Centonze, D.

PY - 2014/12/16

Y1 - 2014/12/16

N2 - Background: Acute optic neuritis is often in association with multiple sclerosis (MS). Proinflammatory cytokines trigger neuronal damage in neuroinflammatory disorders but their role in optic neuritis is poorly investigated. Objective: The objective of this work is to investigate the associations of intrathecal contents of proinflammatory cytokines with transient and persistent dysfunctions after optic neuritis. Methods: In 50 MS patients followed for up to six months, cerebrospinal fluid (CSF) levels of IL-1β, TNF and IL-8 were determined, along with clinical, neurophysiological and morphological measures of optic neuritis severity. Results: Visual impairment, measured by high- and low-contrast visual acuity, and delayed visual-evoked potential (VEP) latencies were significantly correlated to IL-8 levels during optic neuritis. IL-8 at the time of optic neuritis was also associated with persistent demyelination and final axonal loss, inferred by VEP and optical coherence tomography measures, respectively. Contents of IL-8 were correlated to functional visual outcomes, being higher among patients with incomplete recovery. Multivariate analysis confirmed that IL-8 significantly predicted final visual acuity, at equal values of demographics and baseline visual scores. Conclusion: Our study points to IL-8 as the main inflammatory cytokine associated with demyelination and secondary neurodegeneration in the optic nerve after optic neuritis.

AB - Background: Acute optic neuritis is often in association with multiple sclerosis (MS). Proinflammatory cytokines trigger neuronal damage in neuroinflammatory disorders but their role in optic neuritis is poorly investigated. Objective: The objective of this work is to investigate the associations of intrathecal contents of proinflammatory cytokines with transient and persistent dysfunctions after optic neuritis. Methods: In 50 MS patients followed for up to six months, cerebrospinal fluid (CSF) levels of IL-1β, TNF and IL-8 were determined, along with clinical, neurophysiological and morphological measures of optic neuritis severity. Results: Visual impairment, measured by high- and low-contrast visual acuity, and delayed visual-evoked potential (VEP) latencies were significantly correlated to IL-8 levels during optic neuritis. IL-8 at the time of optic neuritis was also associated with persistent demyelination and final axonal loss, inferred by VEP and optical coherence tomography measures, respectively. Contents of IL-8 were correlated to functional visual outcomes, being higher among patients with incomplete recovery. Multivariate analysis confirmed that IL-8 significantly predicted final visual acuity, at equal values of demographics and baseline visual scores. Conclusion: Our study points to IL-8 as the main inflammatory cytokine associated with demyelination and secondary neurodegeneration in the optic nerve after optic neuritis.

KW - Cerebrospinal fluid

KW - IL-8

KW - inflammation

KW - multiple sclerosis

KW - OCT

KW - visual-evoked potentials

UR - http://www.scopus.com/inward/record.url?scp=84924813487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924813487&partnerID=8YFLogxK

U2 - 10.1177/1352458514537365

DO - 10.1177/1352458514537365

M3 - Article

VL - 20

SP - 1841

EP - 1850

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 14

ER -