Interleukin (IL)-6 and receptor activator of nuclear factor (NF)-κB ligand (RANKL) are increased in the serum of a patient with primary pachydermoperiostosis

D. Rendina, G. De Filippo, R. Viceconti, E. Soscia, C. Sirignano, M. Salvatore, M. Della Monica, G. Scarano, G. Mossetti

Research output: Contribution to journalArticlepeer-review

Abstract

Primary pachydermoperiostosis (PDP) is a rare syndrome, characterized by digital clubbing, periostosis, and pachydermia. We have evaluated biochemical bone turnover markers, including components of interleukin-6 (IL-6) and osteoprotegerin/receptor activator of nuclear factor (NF)-κB ligand (OPG/RANKL) systems, in an 18-year-old man affected by primary PDP. The acute phase of the disease was characterized in our patient by high serum levels of IL-6 and RANKL. The observed high serum levels of these parameters are associated with increased values in markers of bone resorption (degradation products of C-terminal telopeptides of type-I collagen and urinary hydroxyproline/creatinine ratio) and reduced serum levels of bone alkaline phosphatase, a marker of bone formation. Serum levels of osteotrophic hormones were in the normal range. Our data suggest that, despite the radiographic findings, the acute phase of primary PDP is characterized by increased bone resorption, probably mediated by IL-6 and RANKL.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalScandinavian Journal of Rheumatology
Volume37
Issue number3
DOIs
Publication statusPublished - 2008

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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