Intermediary metabolism and glycemic control in insulin-dependent diabetic uremic patients treated by continuous peritoneal dialysis

D. Spotti, G. Slaviero, E. La Rocca, A. Cantaluppi, C. Castelnovo, P. Micossi, R. Quartagno, M. Melandri, G. Pozza, C. Ponticelli

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Abstract

The effect on metabolic control and on intermediate metabolism of continuous ambulatory peritoneal dialysis (CAPD) was evaluated in 6 insulin-dependent diabetic uremic patients treated by CAPD, in 6 nondiabetic uremic patients in CAPD and in 6 normal subjects. During the study, 4 dialysis exchanges with 1.36 g/dl dextrose concentration were performed daily; regular insulin was added to the bags in diabetic patients. Our data show a well-controlled mean blood glucose in CAPD diabetic patients by intraperitoneal insulin administration as well as higher insulinemic levels in comparison with those of normal subjects. Plasma lactate and serum glycerol levels were higher and butyrate levels were lower reflecting a continuous ketogenesis inhibition.

Original languageEnglish
Pages (from-to)219-222
Number of pages4
JournalNephron
Volume49
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Nephrology

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    Spotti, D., Slaviero, G., La Rocca, E., Cantaluppi, A., Castelnovo, C., Micossi, P., Quartagno, R., Melandri, M., Pozza, G., & Ponticelli, C. (1988). Intermediary metabolism and glycemic control in insulin-dependent diabetic uremic patients treated by continuous peritoneal dialysis. Nephron, 49(3), 219-222.