Intermediate biomarkers in the colorectal tumor progression

M. Risio, M. P. Rocci

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Intermediate biomarkers are biological alterations in tissue which signal a stage of carcinogenesis between initiation and the development of a malignant tumor. Proliferation biomarkers are those that most satisfy the requisites for premorphological intermediate markers in the colorectal tumor progression. Cell proliferation changes in histologically normal intestinal mucosa are early events directly and closely associated with the morphogenesis of colorectal neoplasia. The transition from the morphological stage and the latter's further progression can be reliably monitored through the use of differentiation and genomic markers. In particular the incidence and the degree of DNA aneuploidy are indicators of the risk of malignant transformation in colorectal adenomas. New 'regression-related' biomarkers should be investigated for the planning of measures designed to bring about the regression of premalignant lesions.

Original languageEnglish
Pages (from-to)16-18
Number of pages3
JournalTumori
Volume81
Issue number3 SUPPL.
Publication statusPublished - 1995

Fingerprint

Colorectal Neoplasms
Biomarkers
Differentiation Antigens
Aneuploidy
Intestinal Mucosa
Morphogenesis
Adenoma
Neoplasms
Carcinogenesis
Cell Proliferation
DNA
Incidence

Keywords

  • apoptosis
  • biomarkers
  • cell proliferation
  • colorectal cancer
  • DNA ploidy

ASJC Scopus subject areas

  • Cancer Research

Cite this

Risio, M., & Rocci, M. P. (1995). Intermediate biomarkers in the colorectal tumor progression. Tumori, 81(3 SUPPL.), 16-18.

Intermediate biomarkers in the colorectal tumor progression. / Risio, M.; Rocci, M. P.

In: Tumori, Vol. 81, No. 3 SUPPL., 1995, p. 16-18.

Research output: Contribution to journalArticle

Risio, M & Rocci, MP 1995, 'Intermediate biomarkers in the colorectal tumor progression', Tumori, vol. 81, no. 3 SUPPL., pp. 16-18.
Risio M, Rocci MP. Intermediate biomarkers in the colorectal tumor progression. Tumori. 1995;81(3 SUPPL.):16-18.
Risio, M. ; Rocci, M. P. / Intermediate biomarkers in the colorectal tumor progression. In: Tumori. 1995 ; Vol. 81, No. 3 SUPPL. pp. 16-18.
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