Abstract
Intermediate biomarkers are biological alterations in tissue which signal a stage of carcinogenesis between initiation and the development of a malignant tumor. Proliferation biomarkers are those that most satisfy the requisites for premorphological intermediate markers in the colorectal tumor progression. Cell proliferation changes in histologically normal intestinal mucosa are early events directly and closely associated with the morphogenesis of colorectal neoplasia. The transition from the morphological stage and the latter's further progression can be reliably monitored through the use of differentiation and genomic markers. In particular the incidence and the degree of DNA aneuploidy are indicators of the risk of malignant transformation in colorectal adenomas. New 'regression-related' biomarkers should be investigated for the planning of measures designed to bring about the regression of premalignant lesions.
| Original language | English |
|---|---|
| Pages (from-to) | 16-18 |
| Number of pages | 3 |
| Journal | Tumori |
| Volume | 81 |
| Issue number | 3 SUPPL. |
| Publication status | Published - 1995 |
Fingerprint
Keywords
- apoptosis
- biomarkers
- cell proliferation
- colorectal cancer
- DNA ploidy
ASJC Scopus subject areas
- Cancer Research
Cite this
Intermediate biomarkers in the colorectal tumor progression. / Risio, M.; Rocci, M. P.
In: Tumori, Vol. 81, No. 3 SUPPL., 1995, p. 16-18.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intermediate biomarkers in the colorectal tumor progression
AU - Risio, M.
AU - Rocci, M. P.
PY - 1995
Y1 - 1995
N2 - Intermediate biomarkers are biological alterations in tissue which signal a stage of carcinogenesis between initiation and the development of a malignant tumor. Proliferation biomarkers are those that most satisfy the requisites for premorphological intermediate markers in the colorectal tumor progression. Cell proliferation changes in histologically normal intestinal mucosa are early events directly and closely associated with the morphogenesis of colorectal neoplasia. The transition from the morphological stage and the latter's further progression can be reliably monitored through the use of differentiation and genomic markers. In particular the incidence and the degree of DNA aneuploidy are indicators of the risk of malignant transformation in colorectal adenomas. New 'regression-related' biomarkers should be investigated for the planning of measures designed to bring about the regression of premalignant lesions.
AB - Intermediate biomarkers are biological alterations in tissue which signal a stage of carcinogenesis between initiation and the development of a malignant tumor. Proliferation biomarkers are those that most satisfy the requisites for premorphological intermediate markers in the colorectal tumor progression. Cell proliferation changes in histologically normal intestinal mucosa are early events directly and closely associated with the morphogenesis of colorectal neoplasia. The transition from the morphological stage and the latter's further progression can be reliably monitored through the use of differentiation and genomic markers. In particular the incidence and the degree of DNA aneuploidy are indicators of the risk of malignant transformation in colorectal adenomas. New 'regression-related' biomarkers should be investigated for the planning of measures designed to bring about the regression of premalignant lesions.
KW - apoptosis
KW - biomarkers
KW - cell proliferation
KW - colorectal cancer
KW - DNA ploidy
UR - http://www.scopus.com/inward/record.url?scp=0029099213&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029099213&partnerID=8YFLogxK
M3 - Article
C2 - 7571048
AN - SCOPUS:0029099213
VL - 81
SP - 16
EP - 18
JO - Tumori
JF - Tumori
SN - 0300-8916
IS - 3 SUPPL.
ER -