TY - JOUR
T1 - Intermittent hypoxia increases exercise tolerance in patients at risk for or with mild COPD
AU - Burtscher, M.
AU - Haider, T.
AU - Domej, W.
AU - Linser, T.
AU - Gatterer, H.
AU - Faulhaber, M.
AU - Pocecco, E.
AU - Ehrenburg, I.
AU - Tkatchuk, E.
AU - Koch, R.
AU - Bernardi, L.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - The effects of repeated short-term hypoxia on exercise tolerance in patients at risk for, or with mild COPD were investigated. Eighteen patients (10 males, 8 females; 33-72 years) were randomly assigned in a double-blind fashion to receive 15 sessions of intermittent hypoxia (FiO
2: 0.15-0.12) or normoxia within 3 weeks. Three weeks of intermittent hypoxia increased total haemoglobin mass (+4% vs. 0%, p <0.05), total exercise time (+9.7% vs. 0%, p <0.05) and the exercise time to the anaerobic threshold (+13% vs. -7.8%, p <0.05) compared to controls. Changes in the total exercise time were positively related to the changes in total haemoglobin mass (r = 0.59, p <0.05) and changes in the time to the anaerobic threshold were positively related to the changes in the lung diffusion capacity for carbon monoxide (r = 0.48, p <0.05). Intermittent hypoxia treatment may be a valuable addition to therapy designed to improve exercise tolerance in patients at risk for, or with mild COPD.
AB - The effects of repeated short-term hypoxia on exercise tolerance in patients at risk for, or with mild COPD were investigated. Eighteen patients (10 males, 8 females; 33-72 years) were randomly assigned in a double-blind fashion to receive 15 sessions of intermittent hypoxia (FiO
2: 0.15-0.12) or normoxia within 3 weeks. Three weeks of intermittent hypoxia increased total haemoglobin mass (+4% vs. 0%, p <0.05), total exercise time (+9.7% vs. 0%, p <0.05) and the exercise time to the anaerobic threshold (+13% vs. -7.8%, p <0.05) compared to controls. Changes in the total exercise time were positively related to the changes in total haemoglobin mass (r = 0.59, p <0.05) and changes in the time to the anaerobic threshold were positively related to the changes in the lung diffusion capacity for carbon monoxide (r = 0.48, p <0.05). Intermittent hypoxia treatment may be a valuable addition to therapy designed to improve exercise tolerance in patients at risk for, or with mild COPD.
KW - COPD
KW - Exercise tolerance
KW - Haemoglobin mass
KW - Intermittent hypoxia
KW - Lung diffusion capacity
KW - Lung function
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U2 - 10.1016/j.resp.2008.10.012
DO - 10.1016/j.resp.2008.10.012
M3 - Article
C2 - 19013544
AN - SCOPUS:57749112868
VL - 165
SP - 97
EP - 103
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
SN - 1569-9048
IS - 1
ER -