Intermittent hypoxia increases exercise tolerance in patients at risk for or with mild COPD

M. Burtscher, T. Haider, W. Domej, T. Linser, H. Gatterer, M. Faulhaber, E. Pocecco, I. Ehrenburg, E. Tkatchuk, R. Koch, L. Bernardi

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of repeated short-term hypoxia on exercise tolerance in patients at risk for, or with mild COPD were investigated. Eighteen patients (10 males, 8 females; 33-72 years) were randomly assigned in a double-blind fashion to receive 15 sessions of intermittent hypoxia (FiO 2: 0.15-0.12) or normoxia within 3 weeks. Three weeks of intermittent hypoxia increased total haemoglobin mass (+4% vs. 0%, p <0.05), total exercise time (+9.7% vs. 0%, p <0.05) and the exercise time to the anaerobic threshold (+13% vs. -7.8%, p <0.05) compared to controls. Changes in the total exercise time were positively related to the changes in total haemoglobin mass (r = 0.59, p <0.05) and changes in the time to the anaerobic threshold were positively related to the changes in the lung diffusion capacity for carbon monoxide (r = 0.48, p <0.05). Intermittent hypoxia treatment may be a valuable addition to therapy designed to improve exercise tolerance in patients at risk for, or with mild COPD.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalRespiratory Physiology and Neurobiology
Volume165
Issue number1
DOIs
Publication statusPublished - Jan 1 2009

Keywords

  • COPD
  • Exercise tolerance
  • Haemoglobin mass
  • Intermittent hypoxia
  • Lung diffusion capacity
  • Lung function

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Intermittent hypoxia increases exercise tolerance in patients at risk for or with mild COPD'. Together they form a unique fingerprint.

Cite this