Internal jugular vein blood flow in multiple sclerosis patients and matched controls

Marcello Mancini, Roberta Lanzillo, Raffaele Liuzzi, Orlando Di Donato, Monica Ragucci, Serena Monti, Elena Salvatore, Vincenzo Brescia Morra, Marco Salvatore

Research output: Contribution to journalArticlepeer-review


The aim of the study was to investigate the Internal Jugular Veins dynamics using contrast enhanced ultrasonography in Multiple Sclerosis patients, clinically isolated syndrome patients and healthy controls. Contrast enhanced ultrasonography imaging of the Internal Jugular Vein was performed in fifty-eight patients with Multiple Sclerosis, seven clinically isolated syndrome patients and in thirteen healthy controls. Time-intensity curves were quantified using a semi-automated method and compared with clinical disease outcomes. Wash-out parameters were calculated and six Time-intensity curves shapes were created. Significantly reduction of wash-out rate in Internal Jugular Veins was detected in Multiple Sclerosis patients compared to healthy controls [22.2% (2.7%-65.9%) vs. 33.4% (16.2%-76.8%); P

Original languageEnglish
Article numbere92730
JournalPLoS One
Issue number3
Publication statusPublished - Mar 27 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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