Internalization and mechanism of action of clostridial toxins in neurons

Carlotta Grumelli, Claudia Verderio, Davide Pozzi, Ornella Rossetto, Cesare Montecucco, Michela Matteoli

Research output: Contribution to journalArticlepeer-review

Abstract

Botulinum toxins are metalloproteases that act inside nerve terminals and block neurotransmitter release via their activity directed specifically on SNARE proteins. This review summarizes data on botulinum toxin modes of binding, sites of action, and biochemical activities. Their use in cell biology and neuroscience is considered, as well as their therapeutic utilization in human diseases characterized by hyperfunction of cholinergic terminals.

Original languageEnglish
Pages (from-to)761-767
Number of pages7
JournalNeuroToxicology
Volume26
Issue number5
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Botulinum toxins
  • Hippocampal neurons
  • Interneurons
  • SNAREs

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Neuroscience(all)
  • Toxicology

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