International collaborative study for the calibration of a proposed international standard for thromboplastin, rabbit, plain

V. Chantarangkul, A. M H P Van Den Besselaar, E. Witteveen, Armando Tripodi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A preparation of rabbit brain thromboplastin, provisionally coded 04/162, is proposed as a candidate for the World Health Organization (WHO) International Standard (IS) for thromboplastin (rabbit, plain), meant to replace the IS coded RBT/90 (rabbit, plain), stocks of which are now exhausted. Results: The preparation was calibrated in an international collaborative study involving 21 laboratories from13 countries and the calibration was performed against the existing WHO-IS (i.e. rTF/95 and OBT/79) and other Certified Reference Materials from the Institute for Reference Materials and Measurements of the European Commission (i.e.CRM149 S) and from the European Action on Anticoagulation (i.e. EUTHR-01). An additional candidate rabbit brain thromboplastin coded as 04/106 was also included in the study. On the basis of predefined criteria (the within- and between-laboratory precision of the calibration and the conformity to the calibration model), 04/162 was the preferred candidate. Conclusions: The assigned International Sensitivity Index value was 1.15 and the inter-laboratory SD and coefficient of variation were 0.057% and 4.9%, respectively.

Original languageEnglish
Pages (from-to)1339-1345
Number of pages7
JournalJournal of Thrombosis and Haemostasis
Volume4
Issue number6
DOIs
Publication statusPublished - Jun 2006

Keywords

  • International Normalized Ratio
  • International Sensitivity Index
  • International Standard
  • Oral anticoagulant treatment
  • Thromboplastin

ASJC Scopus subject areas

  • Medicine(all)

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