International consensus conference on stool banking for faecal microbiota transplantation in clinical practice

Giovanni Cammarota, Gianluca Ianiro, Colleen R Kelly, Benjamin H Mullish, Jessica R Allegretti, Zain Kassam, Lorenza Putignani, Monika Fischer, Josbert J Keller, Samuel Paul Costello, Harry Sokol, Patrizia Kump, Reetta Satokari, Stacy A Kahn, Dina Kao, Perttu Arkkila, Ed J Kuijper, Maria J Gt Vehreschild, Cristina Pintus, Loris Lopetuso & 9 others Luca Masucci, Franco Scaldaferri, E M Terveer, Max Nieuwdorp, Antonio López-Sanromán, Juozas Kupcinskas, Ailsa Hart, Herbert Tilg, Antonio Gasbarrini

Research output: Contribution to journalArticle

Abstract

Although faecal microbiota transplantation (FMT) has a well-established role in the treatment of recurrent Clostridioides difficile infection (CDI), its widespread dissemination is limited by several obstacles, including lack of dedicated centres, difficulties with donor recruitment and complexities related to regulation and safety monitoring. Given the considerable burden of CDI on global healthcare systems, FMT should be widely available to most centres.Stool banks may guarantee reliable, timely and equitable access to FMT for patients and a traceable workflow that ensures safety and quality of procedures. In this consensus project, FMT experts from Europe, North America and Australia gathered and released statements on the following issues related to the stool banking: general principles, objectives and organisation of the stool bank; selection and screening of donors; collection, preparation and storage of faeces; services and clients; registries, monitoring of outcomes and ethical issues; and the evolving role of FMT in clinical practice,Consensus on each statement was achieved through a Delphi process and then in a plenary face-to-face meeting. For each key issue, the best available evidence was assessed, with the aim of providing guidance for the development of stool banks in order to promote accessibility to FMT in clinical practice.

Original languageEnglish
JournalGut
DOIs
Publication statusE-pub ahead of print - Sep 28 2019

Fingerprint

Donor Selection
Safety
Workflow
North America
Infection
Feces
Ethics
Registries
Fecal Microbiota Transplantation
Tissue Donors
Delivery of Health Care
Therapeutics

Cite this

International consensus conference on stool banking for faecal microbiota transplantation in clinical practice. / Cammarota, Giovanni; Ianiro, Gianluca; Kelly, Colleen R; Mullish, Benjamin H; Allegretti, Jessica R; Kassam, Zain; Putignani, Lorenza; Fischer, Monika; Keller, Josbert J; Costello, Samuel Paul; Sokol, Harry; Kump, Patrizia; Satokari, Reetta; Kahn, Stacy A; Kao, Dina; Arkkila, Perttu; Kuijper, Ed J; Vehreschild, Maria J Gt; Pintus, Cristina; Lopetuso, Loris; Masucci, Luca; Scaldaferri, Franco; Terveer, E M; Nieuwdorp, Max; López-Sanromán, Antonio; Kupcinskas, Juozas; Hart, Ailsa; Tilg, Herbert; Gasbarrini, Antonio.

In: Gut, 28.09.2019.

Research output: Contribution to journalArticle

Cammarota, G, Ianiro, G, Kelly, CR, Mullish, BH, Allegretti, JR, Kassam, Z, Putignani, L, Fischer, M, Keller, JJ, Costello, SP, Sokol, H, Kump, P, Satokari, R, Kahn, SA, Kao, D, Arkkila, P, Kuijper, EJ, Vehreschild, MJG, Pintus, C, Lopetuso, L, Masucci, L, Scaldaferri, F, Terveer, EM, Nieuwdorp, M, López-Sanromán, A, Kupcinskas, J, Hart, A, Tilg, H & Gasbarrini, A 2019, 'International consensus conference on stool banking for faecal microbiota transplantation in clinical practice', Gut. https://doi.org/10.1136/gutjnl-2019-319548
Cammarota, Giovanni ; Ianiro, Gianluca ; Kelly, Colleen R ; Mullish, Benjamin H ; Allegretti, Jessica R ; Kassam, Zain ; Putignani, Lorenza ; Fischer, Monika ; Keller, Josbert J ; Costello, Samuel Paul ; Sokol, Harry ; Kump, Patrizia ; Satokari, Reetta ; Kahn, Stacy A ; Kao, Dina ; Arkkila, Perttu ; Kuijper, Ed J ; Vehreschild, Maria J Gt ; Pintus, Cristina ; Lopetuso, Loris ; Masucci, Luca ; Scaldaferri, Franco ; Terveer, E M ; Nieuwdorp, Max ; López-Sanromán, Antonio ; Kupcinskas, Juozas ; Hart, Ailsa ; Tilg, Herbert ; Gasbarrini, Antonio. / International consensus conference on stool banking for faecal microbiota transplantation in clinical practice. In: Gut. 2019.
@article{17bce257e34a46fb821e880fcc42e073,
title = "International consensus conference on stool banking for faecal microbiota transplantation in clinical practice",
abstract = "Although faecal microbiota transplantation (FMT) has a well-established role in the treatment of recurrent Clostridioides difficile infection (CDI), its widespread dissemination is limited by several obstacles, including lack of dedicated centres, difficulties with donor recruitment and complexities related to regulation and safety monitoring. Given the considerable burden of CDI on global healthcare systems, FMT should be widely available to most centres.Stool banks may guarantee reliable, timely and equitable access to FMT for patients and a traceable workflow that ensures safety and quality of procedures. In this consensus project, FMT experts from Europe, North America and Australia gathered and released statements on the following issues related to the stool banking: general principles, objectives and organisation of the stool bank; selection and screening of donors; collection, preparation and storage of faeces; services and clients; registries, monitoring of outcomes and ethical issues; and the evolving role of FMT in clinical practice,Consensus on each statement was achieved through a Delphi process and then in a plenary face-to-face meeting. For each key issue, the best available evidence was assessed, with the aim of providing guidance for the development of stool banks in order to promote accessibility to FMT in clinical practice.",
author = "Giovanni Cammarota and Gianluca Ianiro and Kelly, {Colleen R} and Mullish, {Benjamin H} and Allegretti, {Jessica R} and Zain Kassam and Lorenza Putignani and Monika Fischer and Keller, {Josbert J} and Costello, {Samuel Paul} and Harry Sokol and Patrizia Kump and Reetta Satokari and Kahn, {Stacy A} and Dina Kao and Perttu Arkkila and Kuijper, {Ed J} and Vehreschild, {Maria J Gt} and Cristina Pintus and Loris Lopetuso and Luca Masucci and Franco Scaldaferri and Terveer, {E M} and Max Nieuwdorp and Antonio L{\'o}pez-Sanrom{\'a}n and Juozas Kupcinskas and Ailsa Hart and Herbert Tilg and Antonio Gasbarrini",
note = "{\circledC} Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
month = "9",
day = "28",
doi = "10.1136/gutjnl-2019-319548",
language = "English",
journal = "Gut",
issn = "0017-5749",
publisher = "BMJ Publishing Group",

}

TY - JOUR

T1 - International consensus conference on stool banking for faecal microbiota transplantation in clinical practice

AU - Cammarota, Giovanni

AU - Ianiro, Gianluca

AU - Kelly, Colleen R

AU - Mullish, Benjamin H

AU - Allegretti, Jessica R

AU - Kassam, Zain

AU - Putignani, Lorenza

AU - Fischer, Monika

AU - Keller, Josbert J

AU - Costello, Samuel Paul

AU - Sokol, Harry

AU - Kump, Patrizia

AU - Satokari, Reetta

AU - Kahn, Stacy A

AU - Kao, Dina

AU - Arkkila, Perttu

AU - Kuijper, Ed J

AU - Vehreschild, Maria J Gt

AU - Pintus, Cristina

AU - Lopetuso, Loris

AU - Masucci, Luca

AU - Scaldaferri, Franco

AU - Terveer, E M

AU - Nieuwdorp, Max

AU - López-Sanromán, Antonio

AU - Kupcinskas, Juozas

AU - Hart, Ailsa

AU - Tilg, Herbert

AU - Gasbarrini, Antonio

N1 - © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019/9/28

Y1 - 2019/9/28

N2 - Although faecal microbiota transplantation (FMT) has a well-established role in the treatment of recurrent Clostridioides difficile infection (CDI), its widespread dissemination is limited by several obstacles, including lack of dedicated centres, difficulties with donor recruitment and complexities related to regulation and safety monitoring. Given the considerable burden of CDI on global healthcare systems, FMT should be widely available to most centres.Stool banks may guarantee reliable, timely and equitable access to FMT for patients and a traceable workflow that ensures safety and quality of procedures. In this consensus project, FMT experts from Europe, North America and Australia gathered and released statements on the following issues related to the stool banking: general principles, objectives and organisation of the stool bank; selection and screening of donors; collection, preparation and storage of faeces; services and clients; registries, monitoring of outcomes and ethical issues; and the evolving role of FMT in clinical practice,Consensus on each statement was achieved through a Delphi process and then in a plenary face-to-face meeting. For each key issue, the best available evidence was assessed, with the aim of providing guidance for the development of stool banks in order to promote accessibility to FMT in clinical practice.

AB - Although faecal microbiota transplantation (FMT) has a well-established role in the treatment of recurrent Clostridioides difficile infection (CDI), its widespread dissemination is limited by several obstacles, including lack of dedicated centres, difficulties with donor recruitment and complexities related to regulation and safety monitoring. Given the considerable burden of CDI on global healthcare systems, FMT should be widely available to most centres.Stool banks may guarantee reliable, timely and equitable access to FMT for patients and a traceable workflow that ensures safety and quality of procedures. In this consensus project, FMT experts from Europe, North America and Australia gathered and released statements on the following issues related to the stool banking: general principles, objectives and organisation of the stool bank; selection and screening of donors; collection, preparation and storage of faeces; services and clients; registries, monitoring of outcomes and ethical issues; and the evolving role of FMT in clinical practice,Consensus on each statement was achieved through a Delphi process and then in a plenary face-to-face meeting. For each key issue, the best available evidence was assessed, with the aim of providing guidance for the development of stool banks in order to promote accessibility to FMT in clinical practice.

U2 - 10.1136/gutjnl-2019-319548

DO - 10.1136/gutjnl-2019-319548

M3 - Article

JO - Gut

JF - Gut

SN - 0017-5749

ER -