International guidelines for management of metastatic breast cancer: Combination vs sequential single-agent chemotherapy

Fatima Cardoso, Philippe L. Bedard, Eric P. Winer, Olivia Pagani, Elzbieta Senkus-Konefka, Lesley J. Fallowfield, Stella Kyriakides, Alberto Costa, Tanja Cufer, Kathy S. Albain

Research output: Contribution to journalArticlepeer-review

Abstract

Compared with treatment options for early-stage breast cancer, few data exist regarding the optimal use of chemotherapy for metastatic breast cancer (MBC). The choice of using a combination of cytotoxic chemotherapies vs sequential single agents is controversial. At the 6th European Breast Cancer Conference, the European School of Oncology Metastatic Breast Cancer Task Force convened an open debate on the relative benefits of combination vs sequential therapy. Based on the available data, the Task Force recommends sequential monotherapy as the preferred choice in advanced disease, in the absence of rapid clinical progression, life-threatening visceral metastases, or the need for rapid symptom and/or disease control. Patient- and disease-related factors should be used to choose between combination and sequential single-agent chemotherapy for MBC. Additional research is needed to determine the impact of therapy on patient-rated quality of life and to identify predictive factors that can be used to guide therapy.

Original languageEnglish
Pages (from-to)1174-1181
Number of pages8
JournalJournal of the National Cancer Institute
Volume101
Issue number17
DOIs
Publication statusPublished - Sep 2009

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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