International incidence of childhood cancer, 2001–10: a population-based registry study

E. Steliarova-Foucher, M. Colombet, L.A.G. Ries, F. Moreno, A. Dolya, F. Bray, P. Hesseling, H.Y. Shin, C.A. Stiller, S. Bouzbid, M. Hamdi-Cherif, A. Hablas, E. Chirpaz, N. Buziba, G.C. Chesumbai, S.S. Manraj, D. Reynders, H.R. Wabinga, E. Chokunonga, C.A. LimaC. Asturian Laporte, J.C. de Oliveira, J.P. de Aquino, S.V. Gallagher, C.J. Uribe, L.E. Bravo, M.C. Yepez Chamorro, G. Torres Alvarado, Y.H. Galán Alvarez, F.C. Martinez Reyes, J.C. Castillo Calvas, M. Mendoza Alava, P. Cueva Ayala, B. Hanchard, A. Fajardo-Gutiérrez, D.E. Zavala Zegarra, E. Barrios, C. Nikiforuk, R. Woods, D. Turner, M. MacIntyre, A. Corriveau, T. Navaneelan, C. Bertrand, H. Stuart-Panko, R.J. Wilson, C. Kosary, X. Shen, J. Brockhouse, G.A. Yee, T.C. Mitchell, K. Snipes, D. West, C. Rao, S. Bolick, R.K. Rycroft, L. Mueller, Y. Zheng, K. Dosch, H. Brown, A. Vargas, G.M. Levin, R. Bayakly, C. Johnson, T. Shen, L. Ruppert, C.F. Lynch, S.M. Lai, T.C. Tucker, X.C. Wu, M. Schwenn, K. Stern, S. Gershman, G. Copeland, S. Bushhouse, D.B. Rogers, J. Jackson Thompson, D. Lemons, S. Frederick, J.A. Harris, B. Riddle, A. Stroup, C. Wiggins, M.J. Schymura, L.K. Giljahn, A. Sheikh, S. Schubert, W. Aldinger, J.P. Fulton, M. Whiteside, L. Nogueira, C. Sweeney, A. Johnson, J. Martin, S. Farley, D. Harrelson, R. Malicki, J.R. Espinoza, B.Y. Hernandez, N. Abulfateh, N. Wang, R.K.C. Ngan, K.B. Lingegowda, R. Swaminathan, S.S. Koyande, B. Silverman, K. Ozasa, S. Kanemura, M. Soda, I. Miyashiro, A. Shibata, O. Nimri, Y.J. Won, C.H. Kim, N.S. Hong, H.S. Nam, S. Kweon, W.C. Kim, J.S. Huh, K.W. Jung, C.I. Yoo, A. Elbasmy, A.V. Laudico, M.R. Lumague, H. AlMutlag, R. Buasom, S. Srisukho, J. Tanabodee, S. Wiangnon, D. Pongnikorn, H. Sriplung, O. Dirican, S. Eser, M. Le Hoang, M. Hackl, A. Zborovskaya, N. Dimitrova, Z. Valerianova, M. Sekerija, P. Pavlou, M. Dušek, M. Mägi, J. Clavel, B. Lacour, A.V. Guizard, V. Bouvier, X. Troussard, A.S. Woronoff, B. Tretarre, M. Colonna, F. Molinié, S. Bara, M. Velten, E. Marrer, O. Ganry, P. Grosclaude, P. Kaatsch, S.R. Zeissig, B. Holleczek, A. Katalinic, Z. Jakab, H. Birgisson, P.M. Walsh, L. Mangone, F. Merletti, M. Magoni, S. Ferretti, D. Serraino, G. Spagnoli, M. Fusco, M. Michiara, R. Tumino, F. Falcini, F. Sensi, F. Tisano, S. Piffer, F. Stracci, G. Tagliabue, G. Smailyte, D. Agius, O. Visser, G. Ursin, J. Didkowska, M. Trojanowski, U. Wojciechowska, G. Forjaz de Lacerda, M.A. Silva, J. Laranja Pontes, A. da Costa Miranda, E. Kaiserova, M. Primic Žakelj, R. Peris-Bonet, M.L. Vicente Raneda, E. Almar Marqués, J.R. Quirós Garcia, M. Ramos Monserrat, M. Errezola Saizar, A. Alemán Herrera, J.M. Díaz García, R. Marcos-Gragera, M.J. Sanchez-Perez, E. Ardanaz Aicua, J. Galceran, A. Klint, C.E. Kuehni, C. Bouchardy, F. Levi, A. Bordoni, I. Konzelmann, S. Rohrmann, A.T. Gavin, D.H. Brewster, H. Phung, S. Rushton, S. Guthridge, J. Aitken, K. D'Onise, A. Venn, H. Farrugian, T.J. Threlfall, S. Laumond, L. Yen Kai Sun, J. Hendrix, K. Ballantine, E. Masuyer

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Background Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. Methods This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001–10. Incidence rates per million person-years for the 0–14 years and 0–19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0–4 years, 5–9 years, 10–14 years, and 15–19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0–14 years were compared with comparable data obtained in the 1980s. Findings Of 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001–10. 385 509 incident cases in children aged 0–19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0–14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15–19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0–14 years has increased from 124·0 (95% CI 123·3–124·7) to 140·6 (140·1–141·1) per million person-years. Interpretation This unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research. Funding International Agency for Research on Cancer and the Union for International Cancer Control. © 2017 World Health Organization
Original languageEnglish
Pages (from-to)719-731
Number of pages13
JournalThe Lancet Oncology
Issue number6
Publication statusPublished - 2017


  • adolescent
  • adult
  • age distribution
  • age specific incidence rate
  • age standardized incidence rate
  • Article
  • benign neoplasm
  • cancer control
  • cancer incidence
  • cancer registry
  • central nervous system tumor
  • child
  • childhood cancer
  • controlled study
  • epithelium tumor
  • ethnicity
  • female
  • geographic distribution
  • human
  • infant
  • International Classification of Diseases for Oncology
  • leukemia
  • lymphoma
  • major clinical study
  • male
  • malignant neoplasm
  • melanoma
  • priority journal
  • race
  • sex difference
  • Africa
  • Asia
  • Caribbean
  • ethnology
  • Europe
  • incidence
  • Neoplasms
  • North America
  • Pacific islands
  • preschool child
  • register
  • South America
  • young adult
  • Adolescent
  • Age Distribution
  • Caribbean Region
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Incidence
  • Infant
  • Male
  • Oceania
  • Registries
  • Young Adult


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