International prospective study of distal intestinal obstruction syndrome in cystic fibrosis: Associated factors and outcome

Anne Munck, Corinne Alberti, Carla Colombo, Nataliya Kashirskaya, Helmut Ellemunter, Maria Fotoulaki, Roderick Houwen, Eddy Robberecht, Priscilla Boizeau, Michael Wilschanski

Research output: Contribution to journalArticle

Abstract

Background: Distal intestinal obstruction syndrome (DIOS) is a specific complication of cystic fibrosis. Methods: A study was performed in 10 countries to prospectively evaluate the incidence, associated factors, and treatment modalities in children and adults. Results: 102 patients presented 112 episodes. The incidence of DIOS was similar in children and adults. Medical treatment failed only in cases of complete DIOS (11%). Children with meconium ileus had a higher rate of surgery for DIOS (15% vs. 2%, p = 0.02). Complete DIOS entailed longer hospitalisation (4 [3; 7] days vs. 3 [1; 4], p = 0.002). Delayed arrival at hospital and prior weight loss had a significant impact on the time needed for DIOS resolution. Associated CF co-morbidities for DIOS included meconium ileus (40% vs. 18%, p.

Original languageEnglish
Pages (from-to)531-539
Number of pages9
JournalJournal of Cystic Fibrosis
Volume15
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • Abdominal pain
  • Cystic fibrosis
  • Distal intestinal obstruction syndrome
  • Incidence

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pediatrics, Perinatology, and Child Health

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    Munck, A., Alberti, C., Colombo, C., Kashirskaya, N., Ellemunter, H., Fotoulaki, M., Houwen, R., Robberecht, E., Boizeau, P., & Wilschanski, M. (2016). International prospective study of distal intestinal obstruction syndrome in cystic fibrosis: Associated factors and outcome. Journal of Cystic Fibrosis, 15(4), 531-539. https://doi.org/10.1016/j.jcf.2016.02.002