International therapeutic guidelines for patients with HCV-related extrahepatic disorders. A multidisciplinary expert statement

A. L. Zignego, M. Ramos-Casals, C. Ferri, D. Saadoun, L. Arcaini, D. Roccatello, A. Antonelli, A. C. Desbois, C. Comarmond, L. Gragnani, M. Casato, P. Lamprecht, A. Mangia, A. G. Tzioufas, Z. M. Younossi, P. Cacoub, ISG-EHCV [Unknown]

Research output: Contribution to journalArticlepeer-review

Abstract

Hepatitis C virus (HCV) is both hepatotrophic and lymphotropic virus that causes liver as well extrahepatic manifestations including cryoglobulinemic vasculitis, the most frequent and studied condition, lymphoma, and neurologic, cardiovascular, endocrine-metabolic or renal diseases. HCV-extrahepatic manifestations (HCV-EHMs) may severely affect the overall prognosis, while viral eradication significantly reduces non-liver related deaths. Different clinical manifestations may coexist in the same patient. Due to the variety of HCV clinical manifestations, a multidisciplinary approach along with appropriate therapeutic strategies are required. In the era of interferon-free anti-HCV treatments, international recommendations for the therapeutic management of HCV-EHMs are needed. This implies the need to define the best criteria to use antivirals and/or other therapeutic approaches. The present recommendations, based on qualified expert experience and specific literature, will focus on etiological (antiviral) therapies and/or traditional pathogenetic treatments that still maintain their therapeutic utility.
Original languageEnglish
Pages (from-to)523-541
Number of pages19
JournalAutoimmunity Reviews
Volume16
Issue number5
DOIs
Publication statusPublished - May 1 2017

Keywords

  • Antiviral Agents/therapeutic use
  • Health Planning Guidelines
  • Hepacivirus/metabolism
  • Hepatitis C/complications
  • Humans
  • Anti-HCV therapy
  • Extrahepatic manifestations of HCV
  • Hepatitis C virus (HCV)
  • Non-etiological therapy

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