International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV

EORTC Quality of Life and the EORTC Head and Neck Cancer Groups

Research output: Contribution to journalArticle

Abstract

BACKGROUND: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43).

METHODS: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test-retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons.

RESULTS: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known-groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales.

CONCLUSIONS: Evidence supports the reliability and validity of the EORTC QLQ-HN43 as a measure of quality of life.

Original languageEnglish
Pages (from-to)1725-1737
Number of pages13
JournalHead and Neck Surgery
Volume41
Issue number6
DOIs
Publication statusPublished - Jun 2019

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Head and Neck Neoplasms
Reproducibility of Results
Quality of Life
Statistical Factor Analysis
Survivors
Neck
Head
Therapeutics
Surveys and Questionnaires

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International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43 : Phase IV. / EORTC Quality of Life and the EORTC Head and Neck Cancer Groups.

In: Head and Neck Surgery, Vol. 41, No. 6, 06.2019, p. 1725-1737.

Research output: Contribution to journalArticle

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title = "International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV",
abstract = "BACKGROUND: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43).METHODS: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test-retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons.RESULTS: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known-groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales.CONCLUSIONS: Evidence supports the reliability and validity of the EORTC QLQ-HN43 as a measure of quality of life.",
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AU - EORTC Quality of Life and the EORTC Head and Neck Cancer Groups

AU - Singer, Susanne

AU - Amdal, Cecilie Delphin

AU - Hammerlid, Eva

AU - Tomaszewska, Iwona M

AU - Castro Silva, Joaquim

AU - Mehanna, Hisham

AU - Santos, Marcos

AU - Inhestern, Johanna

AU - Brannan, Christine

AU - Yarom, Noam

AU - Fullerton, Amy

AU - Pinto, Monica

AU - Arraras, Juan I

AU - Kiyota, Naomi

AU - Bonomo, Pierluigi

AU - Sherman, Allen C

AU - Baumann, Ingo

AU - Galalae, Razvan

AU - Fernandez Gonzalez, Loreto

AU - Nicolatou-Galitis, Ourania

AU - Abdel-Hafeez, Zeinab

AU - Raber-Durlacher, Judith

AU - Schmalz, Claudia

AU - Zotti, Paola

AU - Boehm, Andreas

AU - Hofmeister, Dirk

AU - Krejovic Trivic, Sanja

AU - Loo, Suat

AU - Chie, Wei-Chu

AU - Bjordal, Kristin

AU - Brokstad Herlofson, Bente

AU - Grégoire, Vincent

AU - Licitra, Lisa

N1 - © 2019 Wiley Periodicals, Inc.

PY - 2019/6

Y1 - 2019/6

N2 - BACKGROUND: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43).METHODS: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test-retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons.RESULTS: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known-groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales.CONCLUSIONS: Evidence supports the reliability and validity of the EORTC QLQ-HN43 as a measure of quality of life.

AB - BACKGROUND: We validated the new European Organisation for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-HN43).METHODS: We enrolled 812 patients with head and neck cancer from 18 countries. Group 1 completed the questionnaire before therapy, and 3 and 6 months later. In group 2 (survivors), we determined test-retest reliability using intraclass correlation coefficients (ICC). Internal consistency was assessed using Cronbach's Alpha, the scale structure with confirmatory factor analysis, and discriminant validity with known-group comparisons.RESULTS: Cronbach's alpha was >0.70 in 10 of the 12 multi-item scales. All standardized factor loadings exceeded 0.40. The ICC was >0.70 in all but two scales. Differences in scale scores between known-groups were >10 points in 17 of the 19 scales. Sensitivity to change was found to be sufficient in 18 scales.CONCLUSIONS: Evidence supports the reliability and validity of the EORTC QLQ-HN43 as a measure of quality of life.

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DO - 10.1002/hed.25609

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JO - Head and Neck Surgery

JF - Head and Neck Surgery

SN - 1043-3074

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