International Web-based consultation on priorities for translational breast cancer research.

Mitch Dowsett, Aron Goldhirsch, Daniel F. Hayes, Hans Joerg Senn, William Wood, Giuseppe Viale

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Large numbers of translational breast cancer research topics have been completed or are underway, but they differ widely in their immediate and/or future importance to clinical management. We therefore conducted an international Web-based consultation of breast cancer professionals to identify the topics most widely considered to be of highest priority. METHODS: Potential participants were contacted via two large e-mail databases and asked to register, at a Web site, the issues that they felt to be of highest priority. Four hundred nine questions were reduced by a steering committee to 70 unique issues, and registrants were asked to select the 6 questions they considered to be the most important. RESULTS: Votes were recorded from 420 voters (2,520 votes) from 48 countries, with 48% of voters coming from North America. Half of the voters identified themselves as clinicians, with the remainder being academics, research scientists, or pathologists. The highest priority was to identify molecular signatures to select patients who could be spared chemotherapy, which gained about 50% more votes than the second topic and was consistently voted top by voters in North America, Europe, and the rest of the world. Research scientists voted the determination of the role of stem cells in breast cancer development, progression, and treatment sensitivity as the most important issue, but this was considered the sixth priority for clinicians and fourth overall. CONCLUSION: This exercise may bring a greater focus of research resources onto issues voted as top priorities.

Original languageEnglish
JournalBreast Cancer Research
Volume9
Issue number6
Publication statusPublished - 2007

Fingerprint

Referral and Consultation
Breast Neoplasms
North America
Research
Postal Service
Stem Cells
Databases
Exercise
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

International Web-based consultation on priorities for translational breast cancer research. / Dowsett, Mitch; Goldhirsch, Aron; Hayes, Daniel F.; Senn, Hans Joerg; Wood, William; Viale, Giuseppe.

In: Breast Cancer Research, Vol. 9, No. 6, 2007.

Research output: Contribution to journalArticle

@article{d7c37055b9fd474db5e8723ffea4da2d,
title = "International Web-based consultation on priorities for translational breast cancer research.",
abstract = "BACKGROUND: Large numbers of translational breast cancer research topics have been completed or are underway, but they differ widely in their immediate and/or future importance to clinical management. We therefore conducted an international Web-based consultation of breast cancer professionals to identify the topics most widely considered to be of highest priority. METHODS: Potential participants were contacted via two large e-mail databases and asked to register, at a Web site, the issues that they felt to be of highest priority. Four hundred nine questions were reduced by a steering committee to 70 unique issues, and registrants were asked to select the 6 questions they considered to be the most important. RESULTS: Votes were recorded from 420 voters (2,520 votes) from 48 countries, with 48{\%} of voters coming from North America. Half of the voters identified themselves as clinicians, with the remainder being academics, research scientists, or pathologists. The highest priority was to identify molecular signatures to select patients who could be spared chemotherapy, which gained about 50{\%} more votes than the second topic and was consistently voted top by voters in North America, Europe, and the rest of the world. Research scientists voted the determination of the role of stem cells in breast cancer development, progression, and treatment sensitivity as the most important issue, but this was considered the sixth priority for clinicians and fourth overall. CONCLUSION: This exercise may bring a greater focus of research resources onto issues voted as top priorities.",
author = "Mitch Dowsett and Aron Goldhirsch and Hayes, {Daniel F.} and Senn, {Hans Joerg} and William Wood and Giuseppe Viale",
year = "2007",
language = "English",
volume = "9",
journal = "Breast Cancer Research",
issn = "1465-5411",
publisher = "BioMed Central",
number = "6",

}

TY - JOUR

T1 - International Web-based consultation on priorities for translational breast cancer research.

AU - Dowsett, Mitch

AU - Goldhirsch, Aron

AU - Hayes, Daniel F.

AU - Senn, Hans Joerg

AU - Wood, William

AU - Viale, Giuseppe

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Large numbers of translational breast cancer research topics have been completed or are underway, but they differ widely in their immediate and/or future importance to clinical management. We therefore conducted an international Web-based consultation of breast cancer professionals to identify the topics most widely considered to be of highest priority. METHODS: Potential participants were contacted via two large e-mail databases and asked to register, at a Web site, the issues that they felt to be of highest priority. Four hundred nine questions were reduced by a steering committee to 70 unique issues, and registrants were asked to select the 6 questions they considered to be the most important. RESULTS: Votes were recorded from 420 voters (2,520 votes) from 48 countries, with 48% of voters coming from North America. Half of the voters identified themselves as clinicians, with the remainder being academics, research scientists, or pathologists. The highest priority was to identify molecular signatures to select patients who could be spared chemotherapy, which gained about 50% more votes than the second topic and was consistently voted top by voters in North America, Europe, and the rest of the world. Research scientists voted the determination of the role of stem cells in breast cancer development, progression, and treatment sensitivity as the most important issue, but this was considered the sixth priority for clinicians and fourth overall. CONCLUSION: This exercise may bring a greater focus of research resources onto issues voted as top priorities.

AB - BACKGROUND: Large numbers of translational breast cancer research topics have been completed or are underway, but they differ widely in their immediate and/or future importance to clinical management. We therefore conducted an international Web-based consultation of breast cancer professionals to identify the topics most widely considered to be of highest priority. METHODS: Potential participants were contacted via two large e-mail databases and asked to register, at a Web site, the issues that they felt to be of highest priority. Four hundred nine questions were reduced by a steering committee to 70 unique issues, and registrants were asked to select the 6 questions they considered to be the most important. RESULTS: Votes were recorded from 420 voters (2,520 votes) from 48 countries, with 48% of voters coming from North America. Half of the voters identified themselves as clinicians, with the remainder being academics, research scientists, or pathologists. The highest priority was to identify molecular signatures to select patients who could be spared chemotherapy, which gained about 50% more votes than the second topic and was consistently voted top by voters in North America, Europe, and the rest of the world. Research scientists voted the determination of the role of stem cells in breast cancer development, progression, and treatment sensitivity as the most important issue, but this was considered the sixth priority for clinicians and fourth overall. CONCLUSION: This exercise may bring a greater focus of research resources onto issues voted as top priorities.

UR - http://www.scopus.com/inward/record.url?scp=40349103608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40349103608&partnerID=8YFLogxK

M3 - Article

C2 - 18034879

AN - SCOPUS:40349103608

VL - 9

JO - Breast Cancer Research

JF - Breast Cancer Research

SN - 1465-5411

IS - 6

ER -