International workshop on immune tolerance induction: Consensus recommendations

D. M. DiMichele, W. K. Hoots, S. W. Pipe, G. E. Rivard, E. Santagostino

Research output: Contribution to journalArticlepeer-review


Although immune tolerance induction (ITI) has been used for 30 years to eliminate inhibitors and restore normal factor pharmacokinetics in patients with hemophilia, there is a paucity of scientific evidence to guide therapeutic decision-making. In an effort to provide direction for physicians and hemophilia treatment center staff members, an international panel of hemophilia opinion leaders met to develop consensus recommendations for ITI in patients with severe and mild hemophilia A and hemophilia B. These recommendations draw on the available published literature and the collective clinical experience of the group and are rated based on the level of supporting evidence.

Original languageEnglish
Pages (from-to)1-22
Number of pages22
Issue numberSUPPL. 1
Publication statusPublished - Jul 2007


  • Factor IX
  • Factor VIII
  • Hemophilia A
  • Hemophilia B
  • Immune tolerance induction
  • Inhibitors

ASJC Scopus subject areas

  • Hematology


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