Interobserver agreement among pathologists regarding core tissue specimens obtained with a new endoscopic ultrasound histology needle; a prospective multicentre study in 50 cases

Maria Chiara Petrone, Jan Werner Poley, Matteo Bonzini, Pier Alberto Testoni, Ihab Abdulkader, Katharina Biermann, Genevieve Monges, Guido Rindi, Claudio Doglioni, Marco J. Bruno, Marc Giovannini, Julio Iglesias-Garcia, Alberto Larghi, Paolo Giorgio Arcidiacono

Research output: Contribution to journalArticle

Abstract

Aim: To evaluate the interobserver agreement among pathologists in grading the quality of specimens obtained with a new 19-gauge endoscopic ultrasound histology needle. Methods and results: This multicentre prospective study involved 50 slides prepared using material obtained with the new needle. Five experienced pathologists independently reviewed all of the samples, and made assessments of the following features: the presence of a core, the adequacy of the specimen, the interpretability of the specimen, and the possibility of performing additional analyses using the material. Interobserver agreement, determined by Fleiss' kappa statistic and 95% confidence intervals (CIs), was used as the primary outcome measure. Overall, the presence of a core was reported in 88% of cases with good agreement among the pathologists (κ = 0.61; 95% CI 0.52-0.70). The specimens were adequate in 91.2% of cases, and Fleiss' κ was 0.73 (95% CI 0.61-0.81). The interpretation of the specimens was reported to be 'easy' in approximately 87% of cases, with moderate agreement among the pathologists (κ = 0.44; 95% CI 0.35-0.53). The possibility of performing additional analyses from the same sample was rated as positive in approximately 91%, with good agreement (κ = 0.66; 95% CI 0.58-0.75). Conclusions: There was excellent interobserver agreement among pathologists in the assessment of the histological material, especially with regard to sample adequacy.

Original languageEnglish
Pages (from-to)602-608
Number of pages7
JournalHistopathology
Volume62
Issue number4
DOIs
Publication statusPublished - Mar 2013

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Multicenter Studies
Needles
Histology
Prospective Studies
Confidence Intervals
Outcome Assessment (Health Care)
Pathologists

Keywords

  • Endoscopic ultrasound
  • Fine needle biopsy
  • Pathologist agreement

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

Interobserver agreement among pathologists regarding core tissue specimens obtained with a new endoscopic ultrasound histology needle; a prospective multicentre study in 50 cases. / Petrone, Maria Chiara; Poley, Jan Werner; Bonzini, Matteo; Testoni, Pier Alberto; Abdulkader, Ihab; Biermann, Katharina; Monges, Genevieve; Rindi, Guido; Doglioni, Claudio; Bruno, Marco J.; Giovannini, Marc; Iglesias-Garcia, Julio; Larghi, Alberto; Arcidiacono, Paolo Giorgio.

In: Histopathology, Vol. 62, No. 4, 03.2013, p. 602-608.

Research output: Contribution to journalArticle

Petrone, Maria Chiara ; Poley, Jan Werner ; Bonzini, Matteo ; Testoni, Pier Alberto ; Abdulkader, Ihab ; Biermann, Katharina ; Monges, Genevieve ; Rindi, Guido ; Doglioni, Claudio ; Bruno, Marco J. ; Giovannini, Marc ; Iglesias-Garcia, Julio ; Larghi, Alberto ; Arcidiacono, Paolo Giorgio. / Interobserver agreement among pathologists regarding core tissue specimens obtained with a new endoscopic ultrasound histology needle; a prospective multicentre study in 50 cases. In: Histopathology. 2013 ; Vol. 62, No. 4. pp. 602-608.
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abstract = "Aim: To evaluate the interobserver agreement among pathologists in grading the quality of specimens obtained with a new 19-gauge endoscopic ultrasound histology needle. Methods and results: This multicentre prospective study involved 50 slides prepared using material obtained with the new needle. Five experienced pathologists independently reviewed all of the samples, and made assessments of the following features: the presence of a core, the adequacy of the specimen, the interpretability of the specimen, and the possibility of performing additional analyses using the material. Interobserver agreement, determined by Fleiss' kappa statistic and 95{\%} confidence intervals (CIs), was used as the primary outcome measure. Overall, the presence of a core was reported in 88{\%} of cases with good agreement among the pathologists (κ = 0.61; 95{\%} CI 0.52-0.70). The specimens were adequate in 91.2{\%} of cases, and Fleiss' κ was 0.73 (95{\%} CI 0.61-0.81). The interpretation of the specimens was reported to be 'easy' in approximately 87{\%} of cases, with moderate agreement among the pathologists (κ = 0.44; 95{\%} CI 0.35-0.53). The possibility of performing additional analyses from the same sample was rated as positive in approximately 91{\%}, with good agreement (κ = 0.66; 95{\%} CI 0.58-0.75). Conclusions: There was excellent interobserver agreement among pathologists in the assessment of the histological material, especially with regard to sample adequacy.",
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T1 - Interobserver agreement among pathologists regarding core tissue specimens obtained with a new endoscopic ultrasound histology needle; a prospective multicentre study in 50 cases

AU - Petrone, Maria Chiara

AU - Poley, Jan Werner

AU - Bonzini, Matteo

AU - Testoni, Pier Alberto

AU - Abdulkader, Ihab

AU - Biermann, Katharina

AU - Monges, Genevieve

AU - Rindi, Guido

AU - Doglioni, Claudio

AU - Bruno, Marco J.

AU - Giovannini, Marc

AU - Iglesias-Garcia, Julio

AU - Larghi, Alberto

AU - Arcidiacono, Paolo Giorgio

PY - 2013/3

Y1 - 2013/3

N2 - Aim: To evaluate the interobserver agreement among pathologists in grading the quality of specimens obtained with a new 19-gauge endoscopic ultrasound histology needle. Methods and results: This multicentre prospective study involved 50 slides prepared using material obtained with the new needle. Five experienced pathologists independently reviewed all of the samples, and made assessments of the following features: the presence of a core, the adequacy of the specimen, the interpretability of the specimen, and the possibility of performing additional analyses using the material. Interobserver agreement, determined by Fleiss' kappa statistic and 95% confidence intervals (CIs), was used as the primary outcome measure. Overall, the presence of a core was reported in 88% of cases with good agreement among the pathologists (κ = 0.61; 95% CI 0.52-0.70). The specimens were adequate in 91.2% of cases, and Fleiss' κ was 0.73 (95% CI 0.61-0.81). The interpretation of the specimens was reported to be 'easy' in approximately 87% of cases, with moderate agreement among the pathologists (κ = 0.44; 95% CI 0.35-0.53). The possibility of performing additional analyses from the same sample was rated as positive in approximately 91%, with good agreement (κ = 0.66; 95% CI 0.58-0.75). Conclusions: There was excellent interobserver agreement among pathologists in the assessment of the histological material, especially with regard to sample adequacy.

AB - Aim: To evaluate the interobserver agreement among pathologists in grading the quality of specimens obtained with a new 19-gauge endoscopic ultrasound histology needle. Methods and results: This multicentre prospective study involved 50 slides prepared using material obtained with the new needle. Five experienced pathologists independently reviewed all of the samples, and made assessments of the following features: the presence of a core, the adequacy of the specimen, the interpretability of the specimen, and the possibility of performing additional analyses using the material. Interobserver agreement, determined by Fleiss' kappa statistic and 95% confidence intervals (CIs), was used as the primary outcome measure. Overall, the presence of a core was reported in 88% of cases with good agreement among the pathologists (κ = 0.61; 95% CI 0.52-0.70). The specimens were adequate in 91.2% of cases, and Fleiss' κ was 0.73 (95% CI 0.61-0.81). The interpretation of the specimens was reported to be 'easy' in approximately 87% of cases, with moderate agreement among the pathologists (κ = 0.44; 95% CI 0.35-0.53). The possibility of performing additional analyses from the same sample was rated as positive in approximately 91%, with good agreement (κ = 0.66; 95% CI 0.58-0.75). Conclusions: There was excellent interobserver agreement among pathologists in the assessment of the histological material, especially with regard to sample adequacy.

KW - Endoscopic ultrasound

KW - Fine needle biopsy

KW - Pathologist agreement

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