Abstract
Aim: To evaluate the interobserver agreement among pathologists in grading the quality of specimens obtained with a new 19-gauge endoscopic ultrasound histology needle. Methods and results: This multicentre prospective study involved 50 slides prepared using material obtained with the new needle. Five experienced pathologists independently reviewed all of the samples, and made assessments of the following features: the presence of a core, the adequacy of the specimen, the interpretability of the specimen, and the possibility of performing additional analyses using the material. Interobserver agreement, determined by Fleiss' kappa statistic and 95% confidence intervals (CIs), was used as the primary outcome measure. Overall, the presence of a core was reported in 88% of cases with good agreement among the pathologists (κ = 0.61; 95% CI 0.52-0.70). The specimens were adequate in 91.2% of cases, and Fleiss' κ was 0.73 (95% CI 0.61-0.81). The interpretation of the specimens was reported to be 'easy' in approximately 87% of cases, with moderate agreement among the pathologists (κ = 0.44; 95% CI 0.35-0.53). The possibility of performing additional analyses from the same sample was rated as positive in approximately 91%, with good agreement (κ = 0.66; 95% CI 0.58-0.75). Conclusions: There was excellent interobserver agreement among pathologists in the assessment of the histological material, especially with regard to sample adequacy.
| Original language | English |
|---|---|
| Pages (from-to) | 602-608 |
| Number of pages | 7 |
| Journal | Histopathology |
| Volume | 62 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Mar 2013 |
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Keywords
- Endoscopic ultrasound
- Fine needle biopsy
- Pathologist agreement
ASJC Scopus subject areas
- Histology
- Pathology and Forensic Medicine
Cite this
Interobserver agreement among pathologists regarding core tissue specimens obtained with a new endoscopic ultrasound histology needle; a prospective multicentre study in 50 cases. / Petrone, Maria Chiara; Poley, Jan Werner; Bonzini, Matteo; Testoni, Pier Alberto; Abdulkader, Ihab; Biermann, Katharina; Monges, Genevieve; Rindi, Guido; Doglioni, Claudio; Bruno, Marco J.; Giovannini, Marc; Iglesias-Garcia, Julio; Larghi, Alberto; Arcidiacono, Paolo Giorgio.
In: Histopathology, Vol. 62, No. 4, 03.2013, p. 602-608.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interobserver agreement among pathologists regarding core tissue specimens obtained with a new endoscopic ultrasound histology needle; a prospective multicentre study in 50 cases
AU - Petrone, Maria Chiara
AU - Poley, Jan Werner
AU - Bonzini, Matteo
AU - Testoni, Pier Alberto
AU - Abdulkader, Ihab
AU - Biermann, Katharina
AU - Monges, Genevieve
AU - Rindi, Guido
AU - Doglioni, Claudio
AU - Bruno, Marco J.
AU - Giovannini, Marc
AU - Iglesias-Garcia, Julio
AU - Larghi, Alberto
AU - Arcidiacono, Paolo Giorgio
PY - 2013/3
Y1 - 2013/3
N2 - Aim: To evaluate the interobserver agreement among pathologists in grading the quality of specimens obtained with a new 19-gauge endoscopic ultrasound histology needle. Methods and results: This multicentre prospective study involved 50 slides prepared using material obtained with the new needle. Five experienced pathologists independently reviewed all of the samples, and made assessments of the following features: the presence of a core, the adequacy of the specimen, the interpretability of the specimen, and the possibility of performing additional analyses using the material. Interobserver agreement, determined by Fleiss' kappa statistic and 95% confidence intervals (CIs), was used as the primary outcome measure. Overall, the presence of a core was reported in 88% of cases with good agreement among the pathologists (κ = 0.61; 95% CI 0.52-0.70). The specimens were adequate in 91.2% of cases, and Fleiss' κ was 0.73 (95% CI 0.61-0.81). The interpretation of the specimens was reported to be 'easy' in approximately 87% of cases, with moderate agreement among the pathologists (κ = 0.44; 95% CI 0.35-0.53). The possibility of performing additional analyses from the same sample was rated as positive in approximately 91%, with good agreement (κ = 0.66; 95% CI 0.58-0.75). Conclusions: There was excellent interobserver agreement among pathologists in the assessment of the histological material, especially with regard to sample adequacy.
AB - Aim: To evaluate the interobserver agreement among pathologists in grading the quality of specimens obtained with a new 19-gauge endoscopic ultrasound histology needle. Methods and results: This multicentre prospective study involved 50 slides prepared using material obtained with the new needle. Five experienced pathologists independently reviewed all of the samples, and made assessments of the following features: the presence of a core, the adequacy of the specimen, the interpretability of the specimen, and the possibility of performing additional analyses using the material. Interobserver agreement, determined by Fleiss' kappa statistic and 95% confidence intervals (CIs), was used as the primary outcome measure. Overall, the presence of a core was reported in 88% of cases with good agreement among the pathologists (κ = 0.61; 95% CI 0.52-0.70). The specimens were adequate in 91.2% of cases, and Fleiss' κ was 0.73 (95% CI 0.61-0.81). The interpretation of the specimens was reported to be 'easy' in approximately 87% of cases, with moderate agreement among the pathologists (κ = 0.44; 95% CI 0.35-0.53). The possibility of performing additional analyses from the same sample was rated as positive in approximately 91%, with good agreement (κ = 0.66; 95% CI 0.58-0.75). Conclusions: There was excellent interobserver agreement among pathologists in the assessment of the histological material, especially with regard to sample adequacy.
KW - Endoscopic ultrasound
KW - Fine needle biopsy
KW - Pathologist agreement
UR - http://www.scopus.com/inward/record.url?scp=84874213427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874213427&partnerID=8YFLogxK
U2 - 10.1111/his.12041
DO - 10.1111/his.12041
M3 - Article
C2 - 23379782
AN - SCOPUS:84874213427
VL - 62
SP - 602
EP - 608
JO - Histopathology
JF - Histopathology
SN - 0309-0167
IS - 4
ER -