Interobserver agreement in the histologic diagnosis of colorectal polyps: The experience of the multicenter adenoma colorectal study (SMAC)

Massimo Costantini, Stefania Sciallero, Augusto Giannini, Beatrice Gatteschi, Paolo Rinaldi, Giuseppe Lanzanova, Luigina Bonelli, Tino Casetti, Elisabetta Bertinelli, Orietta Giuliani, Guido Castiglione, Paola Mantellini, Carlo Naldoni, Paolo Bruzzi

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Current clinical practice guidelines for patients with colorectal polyps are mainly based on the histologic characteristics of their lesions. However, interobserver variability in the assessment of specific polyp characteristics was evaluated in very few studies. The purpose of this study was to evaluate the interobserver agreement of four pathologists in the diagnosis of histologic type of colorectal polyps and in the degree of dysplasia and of infiltrating carcinoma in adenomas. A stratified random sample of 100 polyps was obtained from the 4,889 polyps resected within the Multicentre Adenoma Colorectal Study (SMAC), and the slides were blindly reviewed by the four pathologists. Agreement was analyzed using kappa statistics. A median kappa of 0.89 (range 0.79-1.0) was estimated for the interobserver agreement for the diagnosis of hyperplastic polyp vs. adenoma. The agreement in the diagnosis of tubular, tubulovillous, and villous type, was given by median kappa values of 0.50, 0.15, and 0.36, respectively. The median kappa for the diagnosis of infiltrating carcinoma was 0.78 (range 0.73-0.84). Agreement on diagnosis of adenoma histologic subtypes, degrees of dysplasia, or infiltrating carcinoma in adenoma was moderate. A simpler classifications might help to better identify patients at different risk of colorectal cancer.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalJournal of Clinical Epidemiology
Volume56
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

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Polyps
Adenoma
Carcinoma
Observer Variation
Practice Guidelines
Colorectal Neoplasms

Keywords

  • Adenoma
  • Agreement
  • Carcinoma
  • Colon
  • Dysplasia
  • Kappa

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Interobserver agreement in the histologic diagnosis of colorectal polyps : The experience of the multicenter adenoma colorectal study (SMAC). / Costantini, Massimo; Sciallero, Stefania; Giannini, Augusto; Gatteschi, Beatrice; Rinaldi, Paolo; Lanzanova, Giuseppe; Bonelli, Luigina; Casetti, Tino; Bertinelli, Elisabetta; Giuliani, Orietta; Castiglione, Guido; Mantellini, Paola; Naldoni, Carlo; Bruzzi, Paolo.

In: Journal of Clinical Epidemiology, Vol. 56, No. 3, 01.03.2003, p. 209-214.

Research output: Contribution to journalArticle

Costantini, Massimo ; Sciallero, Stefania ; Giannini, Augusto ; Gatteschi, Beatrice ; Rinaldi, Paolo ; Lanzanova, Giuseppe ; Bonelli, Luigina ; Casetti, Tino ; Bertinelli, Elisabetta ; Giuliani, Orietta ; Castiglione, Guido ; Mantellini, Paola ; Naldoni, Carlo ; Bruzzi, Paolo. / Interobserver agreement in the histologic diagnosis of colorectal polyps : The experience of the multicenter adenoma colorectal study (SMAC). In: Journal of Clinical Epidemiology. 2003 ; Vol. 56, No. 3. pp. 209-214.
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