Abstract
Aims: To assess the interobserver reproducibility of certain histological features proposed for the diagnosis of melanoma. Methods: In a series of melanomas, 13 histological parameters were analysed: dimension > 6 mm, asymmetry, poor circumscription, irregular confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, cytological atypia, mitoses, dermal lymphocytic infiltrate, and necrosis. Results: The agreement (reproducibility) between the nine observers was excellent (κ > 0.75) for 10 of the 13 examined features (dimension > 6 mm, poor circumscription, irregular confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, mitoses, and necrosis). The agreement for asymmetry was very close to excellence (κ = 0.74), and that for cytological atypia (κ = 0.65) and dermal lymphocytic infiltrate (κ = 0.47) was slightly lower, but in the fair to good agreement range. The κ values obtained by comparison with the majority diagnosis were generally high (≥ 0.85); the mean value of κ was lower (0.70) for only one parameter (dermal lymphocytic infiltrate). Conclusions: The parameters investigated showed an overall good reproducibility.
| Original language | English |
|---|---|
| Pages (from-to) | 1194-1198 |
| Number of pages | 5 |
| Journal | Journal of Clinical Pathology |
| Volume | 58 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2005 |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Interobserver reproducibility of histological features in cutaneous malignant melanoma. / Urso, C.; Rongioletti, F.; Innocenzi, D.; Saieva, C.; Batolo, D.; Chimenti, S.; Filotico, R.; Gianotti, R.; Lentini, M.; Tomasini, C.; Rebora, A.; Pippione, M.
In: Journal of Clinical Pathology, Vol. 58, No. 11, 11.2005, p. 1194-1198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interobserver reproducibility of histological features in cutaneous malignant melanoma
AU - Urso, C.
AU - Rongioletti, F.
AU - Innocenzi, D.
AU - Saieva, C.
AU - Batolo, D.
AU - Chimenti, S.
AU - Filotico, R.
AU - Gianotti, R.
AU - Lentini, M.
AU - Tomasini, C.
AU - Rebora, A.
AU - Pippione, M.
PY - 2005/11
Y1 - 2005/11
N2 - Aims: To assess the interobserver reproducibility of certain histological features proposed for the diagnosis of melanoma. Methods: In a series of melanomas, 13 histological parameters were analysed: dimension > 6 mm, asymmetry, poor circumscription, irregular confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, cytological atypia, mitoses, dermal lymphocytic infiltrate, and necrosis. Results: The agreement (reproducibility) between the nine observers was excellent (κ > 0.75) for 10 of the 13 examined features (dimension > 6 mm, poor circumscription, irregular confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, mitoses, and necrosis). The agreement for asymmetry was very close to excellence (κ = 0.74), and that for cytological atypia (κ = 0.65) and dermal lymphocytic infiltrate (κ = 0.47) was slightly lower, but in the fair to good agreement range. The κ values obtained by comparison with the majority diagnosis were generally high (≥ 0.85); the mean value of κ was lower (0.70) for only one parameter (dermal lymphocytic infiltrate). Conclusions: The parameters investigated showed an overall good reproducibility.
AB - Aims: To assess the interobserver reproducibility of certain histological features proposed for the diagnosis of melanoma. Methods: In a series of melanomas, 13 histological parameters were analysed: dimension > 6 mm, asymmetry, poor circumscription, irregular confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, cytological atypia, mitoses, dermal lymphocytic infiltrate, and necrosis. Results: The agreement (reproducibility) between the nine observers was excellent (κ > 0.75) for 10 of the 13 examined features (dimension > 6 mm, poor circumscription, irregular confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, mitoses, and necrosis). The agreement for asymmetry was very close to excellence (κ = 0.74), and that for cytological atypia (κ = 0.65) and dermal lymphocytic infiltrate (κ = 0.47) was slightly lower, but in the fair to good agreement range. The κ values obtained by comparison with the majority diagnosis were generally high (≥ 0.85); the mean value of κ was lower (0.70) for only one parameter (dermal lymphocytic infiltrate). Conclusions: The parameters investigated showed an overall good reproducibility.
UR - http://www.scopus.com/inward/record.url?scp=27644448780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27644448780&partnerID=8YFLogxK
U2 - 10.1136/jcp.2005.026765
DO - 10.1136/jcp.2005.026765
M3 - Article
C2 - 16254111
AN - SCOPUS:27644448780
VL - 58
SP - 1194
EP - 1198
JO - Journal of Clinical Pathology - Clinical Molecular Pathology
JF - Journal of Clinical Pathology - Clinical Molecular Pathology
SN - 0021-9746
IS - 11
ER -