Interobserver reproducibility of histological features in cutaneous malignant melanoma

C. Urso, F. Rongioletti, D. Innocenzi, C. Saieva, D. Batolo, S. Chimenti, R. Filotico, R. Gianotti, M. Lentini, C. Tomasini, A. Rebora, M. Pippione

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Abstract

Aims: To assess the interobserver reproducibility of certain histological features proposed for the diagnosis of melanoma. Methods: In a series of melanomas, 13 histological parameters were analysed: dimension > 6 mm, asymmetry, poor circumscription, irregular confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, cytological atypia, mitoses, dermal lymphocytic infiltrate, and necrosis. Results: The agreement (reproducibility) between the nine observers was excellent (κ > 0.75) for 10 of the 13 examined features (dimension > 6 mm, poor circumscription, irregular confluent nests, single melanocytes predominating, absence of maturation, suprabasal melanocytes, asymmetrical melanin, melanin in deep cells, mitoses, and necrosis). The agreement for asymmetry was very close to excellence (κ = 0.74), and that for cytological atypia (κ = 0.65) and dermal lymphocytic infiltrate (κ = 0.47) was slightly lower, but in the fair to good agreement range. The κ values obtained by comparison with the majority diagnosis were generally high (≥ 0.85); the mean value of κ was lower (0.70) for only one parameter (dermal lymphocytic infiltrate). Conclusions: The parameters investigated showed an overall good reproducibility.

Original languageEnglish
Pages (from-to)1194-1198
Number of pages5
JournalJournal of Clinical Pathology
Volume58
Issue number11
DOIs
Publication statusPublished - Nov 2005

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ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Urso, C., Rongioletti, F., Innocenzi, D., Saieva, C., Batolo, D., Chimenti, S., Filotico, R., Gianotti, R., Lentini, M., Tomasini, C., Rebora, A., & Pippione, M. (2005). Interobserver reproducibility of histological features in cutaneous malignant melanoma. Journal of Clinical Pathology, 58(11), 1194-1198. https://doi.org/10.1136/jcp.2005.026765