TY - JOUR
T1 - Interobserver reproducibility of the controlled attenuation parameter (CAP) for quantifying liver steatosis
AU - Ferraioli, Giovanna
AU - Tinelli, Carmine
AU - Lissandrin, Raffaella
AU - Zicchetti, Mabel
AU - Rondanelli, Mariangela
AU - Perani, Guido
AU - Bernuzzi, Stefano
AU - Salvaneschi, Laura
AU - Filice, Carlo
PY - 2014/10/2
Y1 - 2014/10/2
N2 - Purpose: This study was conducted to prospectively investigate the interobserver reproducibility of controlled attenuation parameter (CAP) measurements and the relationship among the CAP and body mass index (BMI), gender and age.Methods: Consecutive subjects were studied using the M+ probe of the FibroScan device (Echosens, Paris, France). Measurements were performed by two raters (rater1 and rater2). Interobserver agreement was assessed by using the concordance correlation coefficient (CCC). The Pearson r coefficient was used to test correlation between two study variables, and linear regression was used for the multivariate model.Results: Three hundred fifty-one subjects (227 males and 124 females) were prospectively studied. The CCC was 0.82 (95 % CI 0.78–0.85) overall, 0.80 (95 % CI 0.75–0.85) for BMI 2, 0.76 (95 % CI 0.69–0.84) for BMI 25–29 kg/m2 and 0.65 (95 % CI 0.41–0.88) for BMI ≥30 kg/m2. The CCC was 0.44 (95 % CI 0.31–0.56) for CAP values ≤240 dB/m and 0.72 (95 % CI 0.65–0.79) for CAP values >240 dB/m. In univariate analysis, age and BMI by gender were correlated with the CAP. Multiple regression analysis confirmed the relationship of the CAP with age and BMI, but not with gender.Conclusions: The results of this study show that the interreader agreement in CAP measurement is good. In healthy volunteers, the CAP is strongly correlated with age and BMI.
AB - Purpose: This study was conducted to prospectively investigate the interobserver reproducibility of controlled attenuation parameter (CAP) measurements and the relationship among the CAP and body mass index (BMI), gender and age.Methods: Consecutive subjects were studied using the M+ probe of the FibroScan device (Echosens, Paris, France). Measurements were performed by two raters (rater1 and rater2). Interobserver agreement was assessed by using the concordance correlation coefficient (CCC). The Pearson r coefficient was used to test correlation between two study variables, and linear regression was used for the multivariate model.Results: Three hundred fifty-one subjects (227 males and 124 females) were prospectively studied. The CCC was 0.82 (95 % CI 0.78–0.85) overall, 0.80 (95 % CI 0.75–0.85) for BMI 2, 0.76 (95 % CI 0.69–0.84) for BMI 25–29 kg/m2 and 0.65 (95 % CI 0.41–0.88) for BMI ≥30 kg/m2. The CCC was 0.44 (95 % CI 0.31–0.56) for CAP values ≤240 dB/m and 0.72 (95 % CI 0.65–0.79) for CAP values >240 dB/m. In univariate analysis, age and BMI by gender were correlated with the CAP. Multiple regression analysis confirmed the relationship of the CAP with age and BMI, but not with gender.Conclusions: The results of this study show that the interreader agreement in CAP measurement is good. In healthy volunteers, the CAP is strongly correlated with age and BMI.
KW - Controlled attenuation parameter
KW - Interobserver agreement
KW - Liver steatosis
KW - Noninvasive techniques
KW - Reproducibility studies
KW - Transient elastography
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U2 - 10.1007/s12072-014-9573-1
DO - 10.1007/s12072-014-9573-1
M3 - Article
AN - SCOPUS:84919847133
VL - 8
SP - 576
EP - 581
JO - Hepatology International
JF - Hepatology International
SN - 1936-0533
IS - 4
ER -