Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer

Francesca Giunchi, Kristina Jordahl, Enrico Bollito, Maurizio Colecchia, Carlo Patriarca, Antonietta D’Errico, Francesco Vasuri, Deborah Malvi, Alessandro Fornari, Luca Reggiani Bonetti, Barbara Corti, Mauro Papotti, Paolo DeGiuli, Massimo Loda, Rodolfo Montironi, Michelangelo Fiorentino, Jennifer R. Rider

Research output: Contribution to journalArticle

Abstract

Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.

Original languageEnglish
Pages (from-to)711-715
Number of pages5
JournalVirchows Archiv
Volume470
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Prostatic Intraepithelial Neoplasia
Prostatitis
Atrophy
Prostatic Neoplasms
Prostate
Pathology
Neoplasms
Pathologists

Keywords

  • Atrophic lesions
  • Inflammation
  • PAH
  • Prostate

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer. / Giunchi, Francesca; Jordahl, Kristina; Bollito, Enrico; Colecchia, Maurizio; Patriarca, Carlo; D’Errico, Antonietta; Vasuri, Francesco; Malvi, Deborah; Fornari, Alessandro; Bonetti, Luca Reggiani; Corti, Barbara; Papotti, Mauro; DeGiuli, Paolo; Loda, Massimo; Montironi, Rodolfo; Fiorentino, Michelangelo; Rider, Jennifer R.

In: Virchows Archiv, Vol. 470, No. 6, 01.06.2017, p. 711-715.

Research output: Contribution to journalArticle

Giunchi, F, Jordahl, K, Bollito, E, Colecchia, M, Patriarca, C, D’Errico, A, Vasuri, F, Malvi, D, Fornari, A, Bonetti, LR, Corti, B, Papotti, M, DeGiuli, P, Loda, M, Montironi, R, Fiorentino, M & Rider, JR 2017, 'Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer', Virchows Archiv, vol. 470, no. 6, pp. 711-715. https://doi.org/10.1007/s00428-017-2123-1
Giunchi, Francesca ; Jordahl, Kristina ; Bollito, Enrico ; Colecchia, Maurizio ; Patriarca, Carlo ; D’Errico, Antonietta ; Vasuri, Francesco ; Malvi, Deborah ; Fornari, Alessandro ; Bonetti, Luca Reggiani ; Corti, Barbara ; Papotti, Mauro ; DeGiuli, Paolo ; Loda, Massimo ; Montironi, Rodolfo ; Fiorentino, Michelangelo ; Rider, Jennifer R. / Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer. In: Virchows Archiv. 2017 ; Vol. 470, No. 6. pp. 711-715.
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