Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer

Francesca Giunchi; Kristina Jordahl; Enrico Bollito; Maurizio Colecchia; Carlo Patriarca; Antonietta D’Errico; Francesco Vasuri; Deborah Malvi; Alessandro Fornari; Luca Reggiani Bonetti; Barbara Corti; Mauro Papotti; Paolo DeGiuli; Massimo Loda; Rodolfo Montironi; Michelangelo Fiorentino; Jennifer R. Rider

doi:10.1007/s00428-017-2123-1

Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer

Francesca Giunchi, Kristina Jordahl, Enrico Bollito, Maurizio Colecchia, Carlo Patriarca, Antonietta D’Errico, Francesco Vasuri, Deborah Malvi, Alessandro Fornari, Luca Reggiani Bonetti, Barbara Corti, Mauro Papotti, Paolo DeGiuli, Massimo Loda, Rodolfo Montironi, Michelangelo Fiorentino, Jennifer R. Rider

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.

Original language	English
Pages (from-to)	711-715
Number of pages	5
Journal	Virchows Archiv
Volume	470
Issue number	6
DOIs	https://doi.org/10.1007/s00428-017-2123-1
Publication status	Published - Jun 1 2017

Keywords

Atrophic lesions
Inflammation
PAH
Prostate

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Cell Biology

Access to Document

10.1007/s00428-017-2123-1

Cite this

Giunchi, F., Jordahl, K., Bollito, E., Colecchia, M., Patriarca, C., D’Errico, A., Vasuri, F., Malvi, D., Fornari, A., Bonetti, L. R., Corti, B., Papotti, M., DeGiuli, P., Loda, M., Montironi, R., Fiorentino, M., & Rider, J. R. (2017). Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer. Virchows Archiv, 470(6), 711-715. https://doi.org/10.1007/s00428-017-2123-1

Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer. / Giunchi, Francesca; Jordahl, Kristina; Bollito, Enrico; Colecchia, Maurizio; Patriarca, Carlo; D’Errico, Antonietta; Vasuri, Francesco; Malvi, Deborah; Fornari, Alessandro; Bonetti, Luca Reggiani; Corti, Barbara; Papotti, Mauro; DeGiuli, Paolo; Loda, Massimo; Montironi, Rodolfo; Fiorentino, Michelangelo; Rider, Jennifer R.

In: Virchows Archiv, Vol. 470, No. 6, 01.06.2017, p. 711-715.

Research output: Contribution to journal › Article › peer-review

Giunchi, F, Jordahl, K, Bollito, E, Colecchia, M, Patriarca, C, D’Errico, A, Vasuri, F, Malvi, D, Fornari, A, Bonetti, LR, Corti, B, Papotti, M, DeGiuli, P, Loda, M, Montironi, R, Fiorentino, M & Rider, JR 2017, 'Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer', Virchows Archiv, vol. 470, no. 6, pp. 711-715. https://doi.org/10.1007/s00428-017-2123-1

Giunchi, Francesca ; Jordahl, Kristina ; Bollito, Enrico ; Colecchia, Maurizio ; Patriarca, Carlo ; D’Errico, Antonietta ; Vasuri, Francesco ; Malvi, Deborah ; Fornari, Alessandro ; Bonetti, Luca Reggiani ; Corti, Barbara ; Papotti, Mauro ; DeGiuli, Paolo ; Loda, Massimo ; Montironi, Rodolfo ; Fiorentino, Michelangelo ; Rider, Jennifer R. / Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer. In: Virchows Archiv. 2017 ; Vol. 470, No. 6. pp. 711-715.

@article{774dfa9c121a45e5a00c369a2e15dbdf,

title = "Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer",

abstract = "Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.",

keywords = "Atrophic lesions, Inflammation, PAH, Prostate",

author = "Francesca Giunchi and Kristina Jordahl and Enrico Bollito and Maurizio Colecchia and Carlo Patriarca and Antonietta D{\textquoteright}Errico and Francesco Vasuri and Deborah Malvi and Alessandro Fornari and Bonetti, {Luca Reggiani} and Barbara Corti and Mauro Papotti and Paolo DeGiuli and Massimo Loda and Rodolfo Montironi and Michelangelo Fiorentino and Rider, {Jennifer R.}",

year = "2017",

month = jun,

day = "1",

doi = "10.1007/s00428-017-2123-1",

language = "English",

volume = "470",

pages = "711--715",

journal = "Virchows Archiv - A Pathological Anatomy and Histopathology",

issn = "0945-6317",

publisher = "Springer Verlag",

number = "6",

}

TY - JOUR

T1 - Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer

AU - Giunchi, Francesca

AU - Jordahl, Kristina

AU - Bollito, Enrico

AU - Colecchia, Maurizio

AU - Patriarca, Carlo

AU - D’Errico, Antonietta

AU - Vasuri, Francesco

AU - Malvi, Deborah

AU - Fornari, Alessandro

AU - Bonetti, Luca Reggiani

AU - Corti, Barbara

AU - Papotti, Mauro

AU - DeGiuli, Paolo

AU - Loda, Massimo

AU - Montironi, Rodolfo

AU - Fiorentino, Michelangelo

AU - Rider, Jennifer R.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.

AB - Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.

KW - Atrophic lesions

KW - Inflammation

KW - PAH

KW - Prostate

UR - http://www.scopus.com/inward/record.url?scp=85017450579&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017450579&partnerID=8YFLogxK

U2 - 10.1007/s00428-017-2123-1

DO - 10.1007/s00428-017-2123-1

M3 - Article

C2 - 28405833

AN - SCOPUS:85017450579

VL - 470

SP - 711

EP - 715

JO - Virchows Archiv - A Pathological Anatomy and Histopathology

JF - Virchows Archiv - A Pathological Anatomy and Histopathology

SN - 0945-6317

IS - 6

ER -

Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this