Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer

Francesca Giunchi; Kristina Jordahl; Enrico Bollito; Maurizio Colecchia; Carlo Patriarca; Antonietta D’Errico; Francesco Vasuri; Deborah Malvi; Alessandro Fornari; Luca Reggiani Bonetti; Barbara Corti; Mauro Papotti; Paolo DeGiuli; Massimo Loda; Rodolfo Montironi; Michelangelo Fiorentino; Jennifer R. Rider

doi:10.1007/s00428-017-2123-1

Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer

Francesca Giunchi, Kristina Jordahl, Enrico Bollito, Maurizio Colecchia, Carlo Patriarca, Antonietta D’Errico, Francesco Vasuri, Deborah Malvi, Alessandro Fornari, Luca Reggiani Bonetti, Barbara Corti, Mauro Papotti, Paolo DeGiuli, Massimo Loda, Rodolfo Montironi, Michelangelo Fiorentino, Jennifer R. Rider

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.

Original language	English
Pages (from-to)	711-715
Number of pages	5
Journal	Virchows Archiv
Volume	470
Issue number	6
DOIs	https://doi.org/10.1007/s00428-017-2123-1
Publication status	Published - Jun 1 2017

Keywords

Atrophic lesions
Inflammation
PAH
Prostate

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Biology
Cell Biology

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Giunchi, F., Jordahl, K., Bollito, E., Colecchia, M., Patriarca, C., D’Errico, A., Vasuri, F., Malvi, D., Fornari, A., Bonetti, L. R., Corti, B., Papotti, M., DeGiuli, P., Loda, M., Montironi, R., Fiorentino, M., & Rider, J. R. (2017). Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer. Virchows Archiv, 470(6), 711-715. https://doi.org/10.1007/s00428-017-2123-1

Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer. / Giunchi, Francesca; Jordahl, Kristina; Bollito, Enrico; Colecchia, Maurizio; Patriarca, Carlo; D’Errico, Antonietta; Vasuri, Francesco; Malvi, Deborah; Fornari, Alessandro; Bonetti, Luca Reggiani; Corti, Barbara; Papotti, Mauro; DeGiuli, Paolo; Loda, Massimo; Montironi, Rodolfo; Fiorentino, Michelangelo; Rider, Jennifer R.

In: Virchows Archiv, Vol. 470, No. 6, 01.06.2017, p. 711-715.

Research output: Contribution to journal › Article › peer-review

Giunchi, F, Jordahl, K, Bollito, E, Colecchia, M, Patriarca, C, D’Errico, A, Vasuri, F, Malvi, D, Fornari, A, Bonetti, LR, Corti, B, Papotti, M, DeGiuli, P, Loda, M, Montironi, R, Fiorentino, M & Rider, JR 2017, 'Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer', Virchows Archiv, vol. 470, no. 6, pp. 711-715. https://doi.org/10.1007/s00428-017-2123-1

Giunchi, Francesca ; Jordahl, Kristina ; Bollito, Enrico ; Colecchia, Maurizio ; Patriarca, Carlo ; D’Errico, Antonietta ; Vasuri, Francesco ; Malvi, Deborah ; Fornari, Alessandro ; Bonetti, Luca Reggiani ; Corti, Barbara ; Papotti, Mauro ; DeGiuli, Paolo ; Loda, Massimo ; Montironi, Rodolfo ; Fiorentino, Michelangelo ; Rider, Jennifer R. / Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer. In: Virchows Archiv. 2017 ; Vol. 470, No. 6. pp. 711-715.

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abstract = "Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.",

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AU - Vasuri, Francesco

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AU - Corti, Barbara

AU - Papotti, Mauro

AU - DeGiuli, Paolo

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AU - Fiorentino, Michelangelo

AU - Rider, Jennifer R.

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