TY - JOUR
T1 - Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer
AU - Giunchi, Francesca
AU - Jordahl, Kristina
AU - Bollito, Enrico
AU - Colecchia, Maurizio
AU - Patriarca, Carlo
AU - D’Errico, Antonietta
AU - Vasuri, Francesco
AU - Malvi, Deborah
AU - Fornari, Alessandro
AU - Bonetti, Luca Reggiani
AU - Corti, Barbara
AU - Papotti, Mauro
AU - DeGiuli, Paolo
AU - Loda, Massimo
AU - Montironi, Rodolfo
AU - Fiorentino, Michelangelo
AU - Rider, Jennifer R.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.
AB - Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.
KW - Atrophic lesions
KW - Inflammation
KW - PAH
KW - Prostate
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U2 - 10.1007/s00428-017-2123-1
DO - 10.1007/s00428-017-2123-1
M3 - Article
C2 - 28405833
AN - SCOPUS:85017450579
VL - 470
SP - 711
EP - 715
JO - Virchows Archiv - A Pathological Anatomy and Histopathology
JF - Virchows Archiv - A Pathological Anatomy and Histopathology
SN - 0945-6317
IS - 6
ER -