Interplay between human cytomegalovirus and intrinsic/innate host responses

A complex bidirectional relationship

Giada Rossini, Cristina Cerboni, Angela Santoni, Maria Paola Landini, Santo Landolfo, Deborah Gatti, Giorgio Gribaudo, Stefania Varani

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The interaction between human cytomegalovirus (HCMV) and its host is a complex process that begins with viral attachment and entry into host cells, culminating in the development of a specific adaptive response that clears the acute infection but fails to eradicate HCMV. We review the viral and cellular partners that mediate early host responses to HCMV with regard to the interaction between structural components of virions (viral glycoproteins) and cellular receptors (attachment/entry receptors, toll-like receptors, and other nucleic acid sensors) or intrinsic factors (PML, hDaxx, Sp100, viperin, interferon inducible protein 16), the reactions of innate immune cells (antigen presenting cells and natural killer cells), the numerous mechanisms of viral immunoevasion, and the potential exploitation of events that are associated with early phases of virus-host interplay as a therapeutic strategy.

Original languageEnglish
Article number607276
JournalMediators of Inflammation
Volume2012
DOIs
Publication statusPublished - 2012

Fingerprint

Cytomegalovirus
Viral Structures
Intrinsic Factor
Toll-Like Receptors
Antigen-Presenting Cells
Natural Killer Cells
Virion
Nucleic Acids
Interferons
Glycoproteins
Viruses
Infection
Proteins
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Rossini, G., Cerboni, C., Santoni, A., Landini, M. P., Landolfo, S., Gatti, D., ... Varani, S. (2012). Interplay between human cytomegalovirus and intrinsic/innate host responses: A complex bidirectional relationship. Mediators of Inflammation, 2012, [607276]. https://doi.org/10.1155/2012/607276

Interplay between human cytomegalovirus and intrinsic/innate host responses : A complex bidirectional relationship. / Rossini, Giada; Cerboni, Cristina; Santoni, Angela; Landini, Maria Paola; Landolfo, Santo; Gatti, Deborah; Gribaudo, Giorgio; Varani, Stefania.

In: Mediators of Inflammation, Vol. 2012, 607276, 2012.

Research output: Contribution to journalArticle

Rossini, G, Cerboni, C, Santoni, A, Landini, MP, Landolfo, S, Gatti, D, Gribaudo, G & Varani, S 2012, 'Interplay between human cytomegalovirus and intrinsic/innate host responses: A complex bidirectional relationship', Mediators of Inflammation, vol. 2012, 607276. https://doi.org/10.1155/2012/607276
Rossini, Giada ; Cerboni, Cristina ; Santoni, Angela ; Landini, Maria Paola ; Landolfo, Santo ; Gatti, Deborah ; Gribaudo, Giorgio ; Varani, Stefania. / Interplay between human cytomegalovirus and intrinsic/innate host responses : A complex bidirectional relationship. In: Mediators of Inflammation. 2012 ; Vol. 2012.
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