Interplay between membrane lipid peroxidation, transglutaminase activity, and Cyclooxygenase 2 expression in the tissue adjoining to breast cancer

Maria Luisa Balestrieri, Alessandra Dicitore, Raffaella Benevento, Massimo di Maio, Antonio Santoriello, Silvestro Canonico, Antonio Giordano, Paola Stiuso

Research output: Contribution to journalArticle

Abstract

Breast cancer, a leading cause of cancer related deaths worldwide, is one of the most common neoplasms in women. The increased generation of reactive oxygen species (ROS) in breast lesion is critically involved in the mutagenic processes that drive to breast carcinoma initiation and progression. To date, the molecular events occurring in the tissue adjoin the cancer lesion have not been elucidated. Here, we investigated the role of excess ROS generation during human breast carcinogenesis by evaluating oxidative stress biomarkers, tissue transglutaminase (t-TGase) activity, and expression levels of ubiquitin and cyclooxygenase-2 (COX-2) in the normal tissue adjoin to fibroadenoma (nFA), atypical ductal hyperplasia (nADH), and invasive ductal carcinoma (nIDC) from 45 breast cancer patients. We found that lipid peroxidation and nitric oxide production significantly increased in nIDC respect to nFA and nADH (P2=0.89). Moreover, nIDC and invasive ductal carcinoma (IDC) showed a 10-fold higher t-TGase activity compared to nFA and nADH. Contrary, COX-2 expression levels significantly decreased nIDC and IDC respect to the nFA and nADH (P

Original languageEnglish
Pages (from-to)1577-1582
Number of pages6
JournalJournal of Cellular Physiology
Volume227
Issue number4
DOIs
Publication statusPublished - Apr 2012

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

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