Interplay between mitral regurgitation and transcatheter aortic valve replacement with the corevalve revalving system: A multicenter registry

Francesco Bedogni, Azeem Latib, Federico De Marco, Mauro Agnifili, Jacopo Oreglia, Samuele Pizzocri, Roberto A. Latini, Stefania Lanotte, Anna Sonia Petronio, Marco De Carlo, Federica Ettori, Claudia Fiorina, Arnaldo Poli, Silvia Cirri, Stefano De Servi, Angelo Ramondo, Giuseppe Tarantini, Antonio Marzocchi, Rosario Fiorilli, Silvio KlugmannGian Paolo Ussia, Corrado Tamburino, Francesco Maisano, Nedy Brambilla, Antonio Colombo, Luca Testa

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND - : Little is known of the prognostic significance of mitral regurgitation (MR) on transcatheter aortic valve replacement (TAVR), the impact of TAVR on MR severity, and the variables associated with possible post-TAVR improvement in MR. We evaluated these issues in a multicenter registry of patients undergoing CoreValve Revalving System-TAVR. METHODS AND RESULTS - : Among 1007 consecutive patients, 670 (66.5%), 243 (24.1%), and 94 (9.3%) presented with no/mild, moderate, and severe MR, respectively. At 1 month after TAVR, patients with severe or moderate MR showed comparable mortality rates (odds ratio, 1.1; 95% confidence interval [95% CI], 0.7-1.55; P=0.2), but both were significantly higher compared with patients with mild/no MR (odds ratio, 2.2; 95% CI, 1.78-3.28; P

Original languageEnglish
Pages (from-to)2145-2153
Number of pages9
JournalCirculation
Volume128
Issue number19
DOIs
Publication statusPublished - Nov 5 2013

Keywords

  • aortic valve
  • aortic valve stenosis
  • mitral valve insufficiency

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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