Interplay between mitral regurgitation and transcatheter aortic valve replacement with the corevalve revalving system: A multicenter registry

Francesco Bedogni; Azeem Latib; Federico De Marco; Mauro Agnifili; Jacopo Oreglia; Samuele Pizzocri; Roberto A. Latini; Stefania Lanotte; Anna Sonia Petronio; Marco De Carlo; Federica Ettori; Claudia Fiorina; Arnaldo Poli; Silvia Cirri; Stefano De Servi; Angelo Ramondo; Giuseppe Tarantini; Antonio Marzocchi; Rosario Fiorilli; Silvio Klugmann; Gian Paolo Ussia; Corrado Tamburino; Francesco Maisano; Nedy Brambilla; Antonio Colombo; Luca Testa

doi:10.1161/CIRCULATIONAHA.113.001822

Interplay between mitral regurgitation and transcatheter aortic valve replacement with the corevalve revalving system: A multicenter registry

Francesco Bedogni, Azeem Latib, Federico De Marco, Mauro Agnifili, Jacopo Oreglia, Samuele Pizzocri, Roberto A. Latini, Stefania Lanotte, Anna Sonia Petronio, Marco De Carlo, Federica Ettori, Claudia Fiorina, Arnaldo Poli, Silvia Cirri, Stefano De Servi, Angelo Ramondo, Giuseppe Tarantini, Antonio Marzocchi, Rosario Fiorilli, Silvio KlugmannGian Paolo Ussia, Corrado Tamburino, Francesco Maisano, Nedy Brambilla, Antonio Colombo, Luca Testa

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND - : Little is known of the prognostic significance of mitral regurgitation (MR) on transcatheter aortic valve replacement (TAVR), the impact of TAVR on MR severity, and the variables associated with possible post-TAVR improvement in MR. We evaluated these issues in a multicenter registry of patients undergoing CoreValve Revalving System-TAVR. METHODS AND RESULTS - : Among 1007 consecutive patients, 670 (66.5%), 243 (24.1%), and 94 (9.3%) presented with no/mild, moderate, and severe MR, respectively. At 1 month after TAVR, patients with severe or moderate MR showed comparable mortality rates (odds ratio, 1.1; 95% confidence interval [95% CI], 0.7-1.55; P=0.2), but both were significantly higher compared with patients with mild/no MR (odds ratio, 2.2; 95% CI, 1.78-3.28; P

Original language	English
Pages (from-to)	2145-2153
Number of pages	9
Journal	Circulation
Volume	128
Issue number	19
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.113.001822
Publication status	Published - Nov 5 2013

Keywords

aortic valve
aortic valve stenosis
mitral valve insufficiency

ASJC Scopus subject areas

Physiology (medical)
Cardiology and Cardiovascular Medicine
Medicine(all)

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Bedogni, F., Latib, A., De Marco, F., Agnifili, M., Oreglia, J., Pizzocri, S., Latini, R. A., Lanotte, S., Petronio, A. S., De Carlo, M., Ettori, F., Fiorina, C., Poli, A., Cirri, S., De Servi, S., Ramondo, A., Tarantini, G., Marzocchi, A., Fiorilli, R., ... Testa, L. (2013). Interplay between mitral regurgitation and transcatheter aortic valve replacement with the corevalve revalving system: A multicenter registry. Circulation, 128(19), 2145-2153. https://doi.org/10.1161/CIRCULATIONAHA.113.001822

Interplay between mitral regurgitation and transcatheter aortic valve replacement with the corevalve revalving system : A multicenter registry. / Bedogni, Francesco; Latib, Azeem; De Marco, Federico; Agnifili, Mauro; Oreglia, Jacopo; Pizzocri, Samuele; Latini, Roberto A.; Lanotte, Stefania; Petronio, Anna Sonia; De Carlo, Marco; Ettori, Federica; Fiorina, Claudia; Poli, Arnaldo; Cirri, Silvia; De Servi, Stefano; Ramondo, Angelo; Tarantini, Giuseppe; Marzocchi, Antonio; Fiorilli, Rosario; Klugmann, Silvio; Ussia, Gian Paolo; Tamburino, Corrado; Maisano, Francesco; Brambilla, Nedy; Colombo, Antonio; Testa, Luca.

In: Circulation, Vol. 128, No. 19, 05.11.2013, p. 2145-2153.

Research output: Contribution to journal › Article › peer-review

Bedogni, F, Latib, A, De Marco, F, Agnifili, M, Oreglia, J, Pizzocri, S, Latini, RA, Lanotte, S, Petronio, AS, De Carlo, M, Ettori, F, Fiorina, C, Poli, A, Cirri, S, De Servi, S, Ramondo, A, Tarantini, G, Marzocchi, A, Fiorilli, R, Klugmann, S, Ussia, GP, Tamburino, C, Maisano, F, Brambilla, N, Colombo, A & Testa, L 2013, 'Interplay between mitral regurgitation and transcatheter aortic valve replacement with the corevalve revalving system: A multicenter registry', Circulation, vol. 128, no. 19, pp. 2145-2153. https://doi.org/10.1161/CIRCULATIONAHA.113.001822

Bedogni, Francesco ; Latib, Azeem ; De Marco, Federico ; Agnifili, Mauro ; Oreglia, Jacopo ; Pizzocri, Samuele ; Latini, Roberto A. ; Lanotte, Stefania ; Petronio, Anna Sonia ; De Carlo, Marco ; Ettori, Federica ; Fiorina, Claudia ; Poli, Arnaldo ; Cirri, Silvia ; De Servi, Stefano ; Ramondo, Angelo ; Tarantini, Giuseppe ; Marzocchi, Antonio ; Fiorilli, Rosario ; Klugmann, Silvio ; Ussia, Gian Paolo ; Tamburino, Corrado ; Maisano, Francesco ; Brambilla, Nedy ; Colombo, Antonio ; Testa, Luca. / Interplay between mitral regurgitation and transcatheter aortic valve replacement with the corevalve revalving system : A multicenter registry. In: Circulation. 2013 ; Vol. 128, No. 19. pp. 2145-2153.

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abstract = "BACKGROUND - : Little is known of the prognostic significance of mitral regurgitation (MR) on transcatheter aortic valve replacement (TAVR), the impact of TAVR on MR severity, and the variables associated with possible post-TAVR improvement in MR. We evaluated these issues in a multicenter registry of patients undergoing CoreValve Revalving System-TAVR. METHODS AND RESULTS - : Among 1007 consecutive patients, 670 (66.5%), 243 (24.1%), and 94 (9.3%) presented with no/mild, moderate, and severe MR, respectively. At 1 month after TAVR, patients with severe or moderate MR showed comparable mortality rates (odds ratio, 1.1; 95% confidence interval [95% CI], 0.7-1.55; P=0.2), but both were significantly higher compared with patients with mild/no MR (odds ratio, 2.2; 95% CI, 1.78-3.28; P",

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T2 - A multicenter registry

AU - Bedogni, Francesco

AU - Latib, Azeem

AU - De Marco, Federico

AU - Agnifili, Mauro

AU - Oreglia, Jacopo

AU - Pizzocri, Samuele

AU - Latini, Roberto A.

AU - Lanotte, Stefania

AU - Petronio, Anna Sonia

AU - De Carlo, Marco

AU - Ettori, Federica

AU - Fiorina, Claudia

AU - Poli, Arnaldo

AU - Cirri, Silvia

AU - De Servi, Stefano

AU - Ramondo, Angelo

AU - Tarantini, Giuseppe

AU - Marzocchi, Antonio

AU - Fiorilli, Rosario

AU - Klugmann, Silvio

AU - Ussia, Gian Paolo

AU - Tamburino, Corrado

AU - Maisano, Francesco

AU - Brambilla, Nedy

AU - Colombo, Antonio

AU - Testa, Luca

PY - 2013/11/5

Y1 - 2013/11/5

N2 - BACKGROUND - : Little is known of the prognostic significance of mitral regurgitation (MR) on transcatheter aortic valve replacement (TAVR), the impact of TAVR on MR severity, and the variables associated with possible post-TAVR improvement in MR. We evaluated these issues in a multicenter registry of patients undergoing CoreValve Revalving System-TAVR. METHODS AND RESULTS - : Among 1007 consecutive patients, 670 (66.5%), 243 (24.1%), and 94 (9.3%) presented with no/mild, moderate, and severe MR, respectively. At 1 month after TAVR, patients with severe or moderate MR showed comparable mortality rates (odds ratio, 1.1; 95% confidence interval [95% CI], 0.7-1.55; P=0.2), but both were significantly higher compared with patients with mild/no MR (odds ratio, 2.2; 95% CI, 1.78-3.28; P

AB - BACKGROUND - : Little is known of the prognostic significance of mitral regurgitation (MR) on transcatheter aortic valve replacement (TAVR), the impact of TAVR on MR severity, and the variables associated with possible post-TAVR improvement in MR. We evaluated these issues in a multicenter registry of patients undergoing CoreValve Revalving System-TAVR. METHODS AND RESULTS - : Among 1007 consecutive patients, 670 (66.5%), 243 (24.1%), and 94 (9.3%) presented with no/mild, moderate, and severe MR, respectively. At 1 month after TAVR, patients with severe or moderate MR showed comparable mortality rates (odds ratio, 1.1; 95% confidence interval [95% CI], 0.7-1.55; P=0.2), but both were significantly higher compared with patients with mild/no MR (odds ratio, 2.2; 95% CI, 1.78-3.28; P

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KW - aortic valve stenosis

KW - mitral valve insufficiency

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