Interplay between right ventricular function and cardiac resynchronization therapy: An analysis of the care-HF trial (Cardiac resynchronization-heart Failure)

Thibaud Damy, Stefano Ghio, Alan S. Rigby, Luc Hittinger, Sandra Jacobs, Francisco Leyva, Juan F. Delgado, Jean Claude Daubert, Daniel Gras, Luigi Tavazzi, John G F Cleland

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of this study was to investigate the impact of cardiac resynchronization therapy (CRT) on right ventricular (RV) function and the influence of RV dysfunction on the echocardiographic and clinical response to CRT among patients enrolled in the CARE-HF (Cardiac Resynchronization-Heart Failure) trial. Background: Cardiac resynchronization therapy prolongs survival in appropriately selected patients with heart failure but the benefit might be diminished in patients with RV dysfunction. Methods: Of 813 patients enrolled in the CARE-HF study, 688 had tricuspid plane systolic excursion (TAPSE) measured at baseline, and 345 of these were assigned to CRT. Their median (interquartile range) age was 66 (58 to 71) years, left ventricular (LV) ejection fraction was 24% (21% to 28%), and TAPSE was 19 (16 to 22) mm. Baseline LV function and size and QRS duration were similar among TAPSE tertiles, but those in the worst tertile (TAPSE

Original languageEnglish
Pages (from-to)2153-2160
Number of pages8
JournalJournal of the American College of Cardiology
Volume61
Issue number21
DOIs
Publication statusPublished - May 28 2013

Keywords

  • chronic heart failure
  • prognosis
  • resynchronization
  • right ventricle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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