TY - JOUR
T1 - Interplay between right ventricular function and cardiac resynchronization therapy
T2 - An analysis of the care-HF trial (Cardiac resynchronization-heart Failure)
AU - Damy, Thibaud
AU - Ghio, Stefano
AU - Rigby, Alan S.
AU - Hittinger, Luc
AU - Jacobs, Sandra
AU - Leyva, Francisco
AU - Delgado, Juan F.
AU - Daubert, Jean Claude
AU - Gras, Daniel
AU - Tavazzi, Luigi
AU - Cleland, John G F
PY - 2013/5/28
Y1 - 2013/5/28
N2 - Objectives: The aim of this study was to investigate the impact of cardiac resynchronization therapy (CRT) on right ventricular (RV) function and the influence of RV dysfunction on the echocardiographic and clinical response to CRT among patients enrolled in the CARE-HF (Cardiac Resynchronization-Heart Failure) trial. Background: Cardiac resynchronization therapy prolongs survival in appropriately selected patients with heart failure but the benefit might be diminished in patients with RV dysfunction. Methods: Of 813 patients enrolled in the CARE-HF study, 688 had tricuspid plane systolic excursion (TAPSE) measured at baseline, and 345 of these were assigned to CRT. Their median (interquartile range) age was 66 (58 to 71) years, left ventricular (LV) ejection fraction was 24% (21% to 28%), and TAPSE was 19 (16 to 22) mm. Baseline LV function and size and QRS duration were similar among TAPSE tertiles, but those in the worst tertile (TAPSE
AB - Objectives: The aim of this study was to investigate the impact of cardiac resynchronization therapy (CRT) on right ventricular (RV) function and the influence of RV dysfunction on the echocardiographic and clinical response to CRT among patients enrolled in the CARE-HF (Cardiac Resynchronization-Heart Failure) trial. Background: Cardiac resynchronization therapy prolongs survival in appropriately selected patients with heart failure but the benefit might be diminished in patients with RV dysfunction. Methods: Of 813 patients enrolled in the CARE-HF study, 688 had tricuspid plane systolic excursion (TAPSE) measured at baseline, and 345 of these were assigned to CRT. Their median (interquartile range) age was 66 (58 to 71) years, left ventricular (LV) ejection fraction was 24% (21% to 28%), and TAPSE was 19 (16 to 22) mm. Baseline LV function and size and QRS duration were similar among TAPSE tertiles, but those in the worst tertile (TAPSE
KW - chronic heart failure
KW - prognosis
KW - resynchronization
KW - right ventricle
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U2 - 10.1016/j.jacc.2013.02.049
DO - 10.1016/j.jacc.2013.02.049
M3 - Article
C2 - 23541971
AN - SCOPUS:84877986252
VL - 61
SP - 2153
EP - 2160
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 21
ER -