Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma

Serena De Matteis, Anna Maria Granato, Roberta Napolitano, Chiara Molinari, Martina Valgiusti, Daniele Santini, Francesco Giuseppe Foschi, Giorgio Ercolani, Umberto Vespasiani Gentilucci, Luca Faloppi, Mario Scartozzi, Giovanni Luca Frassineti, Andrea Casadei Gardini

Research output: Contribution to journalReview article

Abstract

Sirtuins (SIRT), first described as nicotinamide adenine dinucleotide (NAD+)-dependent type III histone deacetylases, are produced by cells to support in the defense against chronic stress conditions such as metabolic syndromes, neurodegeneration, and cancer. SIRT-3 is one of the most studied members of the mitochondrial sirtuins family. In particular, its involvement in metabolic diseases and its dual role in cancer have been described. In the present review, based on the evidence of SIRT-3 involvement in metabolic dysfunctions, we aimed to provide an insight into the multifaceted role of SIRT-3 in many solid and hematological tumors with a particular focus on hepatocellular carcinoma (HCC). SIRT-3 regulatory effect and involvement in metabolism dysfunctions may have strong implications in HCC development and treatment. Research literature widely reports the relationship between metabolic disorders and HCC development. This evidence suggests a putative bridge role of SIRT-3 between metabolic diseases and HCC. However, further studies are necessary to demonstrate such interconnection.

Original languageEnglish
Pages (from-to)1872-1880
Number of pages9
JournalDigestive Diseases and Sciences
Volume62
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

Keywords

  • Hepatocellular carcinoma
  • Metabolism
  • SIRT-3
  • Tumor suppressor

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

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  • Cite this

    De Matteis, S., Granato, A. M., Napolitano, R., Molinari, C., Valgiusti, M., Santini, D., Foschi, F. G., Ercolani, G., Vespasiani Gentilucci, U., Faloppi, L., Scartozzi, M., Frassineti, G. L., & Casadei Gardini, A. (2017). Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma. Digestive Diseases and Sciences, 62(8), 1872-1880. https://doi.org/10.1007/s10620-017-4615-x