Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis

Cecilia Marini, Silvia Morbelli, Angelina Cistaro, Cristina Campi, Claudia Caponnetto, Matteo Bauckneht, Alessandro Bellini, Ambra Buschiazzo, Iolanda Calamia, Mauro C. Beltrametti, Simone Margotti, Piercarlo Fania, Ilaria Poggi, Corrado Cabona, Selene Capitanio, Roberta Piva, Andrea Calvo, Cristina Moglia, Antonio Canosa, Anna Maria MassoneFlavio Nobili, Gianluigi Mancardi, Adriano Chio, Michele Piana, Gianmario Sambuceti

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We recently reported the potential of Hough transform in delineating spinal cord metabolism by 18F-fluorodeoxyglucose PET/CT scanning in amyotrophic lateral sclerosis. The present study aimed to verify the relationship between spinal cord and brain metabolism in 44 prospectively recruited patients affected by amyotrophic lateral sclerosis submitted to 18F-fluorodeoxyglucose brain and whole-body PET/CT. Patients were studied to highlight the presence of brain hypo-or hypermetabolism with respect to healthy controls, and multiple regression analysis was performed to evaluate the correlation between spinal cord and brain metabolism. Our results confirmed higher 18F-fluorodeoxyglucose uptake in both cervical and dorsal spinal cord in patients with amyotrophic lateral sclerosis with respect to controls. This finding was paralleled by the opposite pattern in the brain cortex that showed a generalized reduction in tracer uptake. This hypometabolism was particularly evident in wide regions of the frontal-dorsolateral cortex while it did not involve the midbrain. Bulbar and spinal disease onset was associated with similar degree of metabolic activation in the spinal cord. However, among spinal onset patients, upper limb presentation was associated with a more pronounced metabolic activation of cervical segment. Obtained data suggest a differential neuro-pathological state or temporal sequence in disease progression.

Original languageEnglish
Pages (from-to)2272-2279
Number of pages8
JournalBrain
Volume141
Issue number8
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Amyotrophic Lateral Sclerosis
Cerebral Cortex
Spinal Cord
Fluorodeoxyglucose F18
Brain
Spinal Diseases
Frontal Lobe
Mesencephalon
Upper Extremity
Disease Progression
Regression Analysis
Metabolic Activation

Keywords

  • amyotrophic lateral sclerosis
  • neurodegeneration biomarkers
  • neuroinflammation
  • neuromuscular disease imaging
  • upper motor neuron

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis. / Marini, Cecilia; Morbelli, Silvia; Cistaro, Angelina; Campi, Cristina; Caponnetto, Claudia; Bauckneht, Matteo; Bellini, Alessandro; Buschiazzo, Ambra; Calamia, Iolanda; Beltrametti, Mauro C.; Margotti, Simone; Fania, Piercarlo; Poggi, Ilaria; Cabona, Corrado; Capitanio, Selene; Piva, Roberta; Calvo, Andrea; Moglia, Cristina; Canosa, Antonio; Massone, Anna Maria; Nobili, Flavio; Mancardi, Gianluigi; Chio, Adriano; Piana, Michele; Sambuceti, Gianmario.

In: Brain, Vol. 141, No. 8, 01.01.2018, p. 2272-2279.

Research output: Contribution to journalArticle

Marini, C, Morbelli, S, Cistaro, A, Campi, C, Caponnetto, C, Bauckneht, M, Bellini, A, Buschiazzo, A, Calamia, I, Beltrametti, MC, Margotti, S, Fania, P, Poggi, I, Cabona, C, Capitanio, S, Piva, R, Calvo, A, Moglia, C, Canosa, A, Massone, AM, Nobili, F, Mancardi, G, Chio, A, Piana, M & Sambuceti, G 2018, 'Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis', Brain, vol. 141, no. 8, pp. 2272-2279. https://doi.org/10.1093/brain/awy152
Marini, Cecilia ; Morbelli, Silvia ; Cistaro, Angelina ; Campi, Cristina ; Caponnetto, Claudia ; Bauckneht, Matteo ; Bellini, Alessandro ; Buschiazzo, Ambra ; Calamia, Iolanda ; Beltrametti, Mauro C. ; Margotti, Simone ; Fania, Piercarlo ; Poggi, Ilaria ; Cabona, Corrado ; Capitanio, Selene ; Piva, Roberta ; Calvo, Andrea ; Moglia, Cristina ; Canosa, Antonio ; Massone, Anna Maria ; Nobili, Flavio ; Mancardi, Gianluigi ; Chio, Adriano ; Piana, Michele ; Sambuceti, Gianmario. / Interplay between spinal cord and cerebral cortex metabolism in amyotrophic lateral sclerosis. In: Brain. 2018 ; Vol. 141, No. 8. pp. 2272-2279.
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abstract = "We recently reported the potential of Hough transform in delineating spinal cord metabolism by 18F-fluorodeoxyglucose PET/CT scanning in amyotrophic lateral sclerosis. The present study aimed to verify the relationship between spinal cord and brain metabolism in 44 prospectively recruited patients affected by amyotrophic lateral sclerosis submitted to 18F-fluorodeoxyglucose brain and whole-body PET/CT. Patients were studied to highlight the presence of brain hypo-or hypermetabolism with respect to healthy controls, and multiple regression analysis was performed to evaluate the correlation between spinal cord and brain metabolism. Our results confirmed higher 18F-fluorodeoxyglucose uptake in both cervical and dorsal spinal cord in patients with amyotrophic lateral sclerosis with respect to controls. This finding was paralleled by the opposite pattern in the brain cortex that showed a generalized reduction in tracer uptake. This hypometabolism was particularly evident in wide regions of the frontal-dorsolateral cortex while it did not involve the midbrain. Bulbar and spinal disease onset was associated with similar degree of metabolic activation in the spinal cord. However, among spinal onset patients, upper limb presentation was associated with a more pronounced metabolic activation of cervical segment. Obtained data suggest a differential neuro-pathological state or temporal sequence in disease progression.",
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AU - Caponnetto, Claudia

AU - Bauckneht, Matteo

AU - Bellini, Alessandro

AU - Buschiazzo, Ambra

AU - Calamia, Iolanda

AU - Beltrametti, Mauro C.

AU - Margotti, Simone

AU - Fania, Piercarlo

AU - Poggi, Ilaria

AU - Cabona, Corrado

AU - Capitanio, Selene

AU - Piva, Roberta

AU - Calvo, Andrea

AU - Moglia, Cristina

AU - Canosa, Antonio

AU - Massone, Anna Maria

AU - Nobili, Flavio

AU - Mancardi, Gianluigi

AU - Chio, Adriano

AU - Piana, Michele

AU - Sambuceti, Gianmario

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