Interplay of Cu,Zn Superoxide Dismutase and Nitric Oxide Synthase in Neurodegenerative Processes

Giuseppe Rotilio, Karia Aquilano, Maria Rosa Ciriolo

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Reactive oxygen and nitrogen species (ROS and RNS) have been extensively recognized as important signaling molecules implicated in physiological processes such as gene expression, cell differentiation and immune activation. Nevertheless, continuous production of these species may produce oxidative and/or nitrosative stress resulting in cell damage and ultimately leading to cell death. Due to the high oxygen consumption and relative poor antioxidant defense, the central nervous system is highly susceptible to ROS- and RNS-mediated toxicity. Actually, the oxidative and nitrosative stress have been implicated in the pathogenesis of neurodegeneration of a large variety of neurological disorders. This review will cover some aspects of the involvement of ROS- and RNS-mediated apoptotic processes occurring in cellular models of familial amyotrophic lateral sclerosis (FALS), in particular the cases associated with mutations in SOD1, the gene encoding Cu,Zn superoxide dismutase (Cu,Zn SOD). A possible role for proteasome in the inhibition of neurodegenerative process by balancing ROS and RNS species is envisaged on the basis of evidence provided by results obtained from studies on this experimental model.

Original languageEnglish
Pages (from-to)629-634
Number of pages6
JournalIUBMB Life
Volume55
Issue number10-11
DOIs
Publication statusPublished - Oct 2003

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Physiological Phenomena
Reactive Nitrogen Species
Proteasome Endopeptidase Complex
Nervous System Diseases
Oxygen Consumption
Nitric Oxide Synthase
Cell Differentiation
Reactive Oxygen Species
Oxidative Stress
Cell Death
Theoretical Models
Central Nervous System
Antioxidants
Gene Expression
Mutation
Gene encoding
Neurology
Cell death
Gene expression
Genes

Keywords

  • ALS
  • Carbonyls
  • Nitric oxide
  • nNOS
  • Proteasome
  • ROS

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Interplay of Cu,Zn Superoxide Dismutase and Nitric Oxide Synthase in Neurodegenerative Processes. / Rotilio, Giuseppe; Aquilano, Karia; Ciriolo, Maria Rosa.

In: IUBMB Life, Vol. 55, No. 10-11, 10.2003, p. 629-634.

Research output: Contribution to journalArticle

Rotilio, Giuseppe ; Aquilano, Karia ; Ciriolo, Maria Rosa. / Interplay of Cu,Zn Superoxide Dismutase and Nitric Oxide Synthase in Neurodegenerative Processes. In: IUBMB Life. 2003 ; Vol. 55, No. 10-11. pp. 629-634.
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