Interpretation of genotypic HIV-1 resistance to darunavir and virological response: Validation of available systems and of a new score

Andrea De Luca, Simona Di Giambenedetto, Renato Maserati, Nicola Gianotti, Pasquale Narciso, Andrea Antinori, Giovanni Di Perri, Mattia C F Prosperi, Fausto Baldanti, Valeria Micheli, Maurizio Zazzi, Carlo F. Perno, Maria M. Santoro

Research output: Contribution to journalArticlepeer-review

Abstract

Background: There is not yet consensus on interpretation of genotypic HIV-1 resistance to darunavir (DRV). We validated existing rules and a newly derived score. Methods: Protease inhibitor (PI)-failing patients starting a DRV/ritonavir-based regimen, with available baseline resistance genotypes, were extracted from three Italian databases. Virological response (VR) was analysed between 4 and 32 follow-up weeks, defined as a drop from baseline HIV RNA of ≥2 log10 or a value 12 weeks of follow-up. DRV/ritonavir resistance was interpreted by seven algorithms. A new weighted score (DRV-2009) was derived and validated, analysing associations of protease mutations with VR. Results: A total of 217 patients were analysed, with a mean (±sd) follow-up time of 17 (±9) weeks. At baseline, median HIV RNA was 4.26 log10 copies/ml (IQR 3.11-5.03); VR was achieved in 135/217 (62%) patients. Adjusting for use of a new drug class, number of previous PIs experienced, CD4+ T-cell count and HIV RNA, only the Rega DRV/ritonavir interpretation was significantly associated with VR (per increase in susceptibility category, OR 1.94, 95% CI 1.32-2.86; P

Original languageEnglish
Pages (from-to)489-497
Number of pages9
JournalAntiviral Therapy
Volume16
Issue number4
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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