Interpretation of p16, p53 and mismatch repair protein immunohistochemistry in gynaecological neoplasia

Richard Wing-Cheuk Wong, Andrea Palicelli, Lien Hoang, Naveena Singh

Research output: Contribution to journalReview articlepeer-review

Abstract

Current management of gynaecological neoplasms is underpinned by their molecular characteristics. For many neoplasms the underlying genetic abnormalities can be reliably detected using immunohistochemistry for protein expression as a surrogate. The three most widely utilized biomarkers in this regard in gynaecological neoplasms are p16, p53 and mismatch repair (MMR) proteins, and it is vital for all pathologists to be aware of the indications for their use, correct interpretation of expression patterns, awareness of technical and interpretive pitfalls as well as appropriate reporting terminology.

Original languageEnglish
Pages (from-to)257-277
Number of pages21
JournalDiagnostic Histopathology
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • endometrial carcinoma
  • high-grade serous carcinoma
  • immunohistochemistry
  • intraepithelial neoplasia
  • mismatch repair
  • p16
  • p53
  • vulval squamous cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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