Interpretation of the complexity of innate immune responses by functional genomics

Paola Ricciardi-Castagnoli, Francesca Granucci

Research output: Contribution to journalArticlepeer-review


Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.

Original languageEnglish
Pages (from-to)881-888
Number of pages8
JournalNature Reviews Immunology
Issue number11
Publication statusPublished - Nov 2002

ASJC Scopus subject areas

  • Immunology


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