Abstract
Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.
| Original language | English |
|---|---|
| Pages (from-to) | 881-888 |
| Number of pages | 8 |
| Journal | Nature Reviews Immunology |
| Volume | 2 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2002 |
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ASJC Scopus subject areas
- Immunology
Cite this
Interpretation of the complexity of innate immune responses by functional genomics. / Ricciardi-Castagnoli, Paola; Granucci, Francesca.
In: Nature Reviews Immunology, Vol. 2, No. 11, 11.2002, p. 881-888.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Interpretation of the complexity of innate immune responses by functional genomics
AU - Ricciardi-Castagnoli, Paola
AU - Granucci, Francesca
PY - 2002/11
Y1 - 2002/11
N2 - Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.
AB - Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.
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U2 - 10.1038/nri936
DO - 10.1038/nri936
M3 - Article
VL - 2
SP - 881
EP - 888
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
SN - 1474-1733
IS - 11
ER -