Interpretation of the complexity of innate immune responses by functional genomics

Paola Ricciardi-Castagnoli, Francesca Granucci

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Understanding how the immune system is regulated and responds to pathogens will require whole-system approaches, because the study of single immunological parameters has, so far, been unable to unlock immune-system complexity. Global transcription analysis using microarray technologies provides a new approach to the description of complex biological phenomena. Here, we discuss insights into innate immunity that have been provided by genome-wide approaches and their impact on the interpretation of immune-system complexity.

Original languageEnglish
Pages (from-to)881-888
Number of pages8
JournalNature Reviews Immunology
Volume2
Issue number11
DOIs
Publication statusPublished - Nov 2002

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Genomics
Innate Immunity
Immune System
Biological Phenomena
Microarray Analysis
Genome
Technology

ASJC Scopus subject areas

  • Immunology

Cite this

Interpretation of the complexity of innate immune responses by functional genomics. / Ricciardi-Castagnoli, Paola; Granucci, Francesca.

In: Nature Reviews Immunology, Vol. 2, No. 11, 11.2002, p. 881-888.

Research output: Contribution to journalArticle

Ricciardi-Castagnoli, Paola ; Granucci, Francesca. / Interpretation of the complexity of innate immune responses by functional genomics. In: Nature Reviews Immunology. 2002 ; Vol. 2, No. 11. pp. 881-888.
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