Interrater agreement for final infarct mri lesion delineation

Anders B. Neumann, Kristjana Y. Jonsdottir, Kim Mouridsen, Niels Hjort, Carsten Gyldensted, Alberto Bizzi, Jens Fiehler, Roberto Gasparotti, Jonathan H. Gillard, Marc Hermier, Thomas Kucinski, Elna Marie Larsson, Leif Sørensen, Leif Østergaard

Research output: Contribution to journalArticlepeer-review


Background and Purpose-Lesion volume measured on follow-up magnetic resonance imaging (MRI) is commonly used as an outcome parameter in clinical stroke trials. However, few studies have evaluated the optimal sequence choice and the interrater reliability of this outcome measure. The objective of this study was to quantify the geometric interrater agreement for lesion delineation of chronic infarcts on T2-weighted and fluid-attenuated inverse recovery (FLAIR) MRI. Methods-In a retrospective study of 14 patients, lesions on 90-day follow-up FLAIR and T2 fast spin echo MRI were outlined by 9 independent, blinded, experienced neuroradiologists. Voxel-wise interrater agreement was measured as (1) the volume of the intersection of individual rater's lesion outlines relative to the mean lesion volume (overlap ratio) and (2) the Hausdorff distance between the lesion markings. Results-Mean patient age was 64.4 years (range, 45 to 79). Lesion volumes on FLAIR were, on average, 2.5 mL greater than were T2 volumes (median; P

Original languageEnglish
Pages (from-to)3768-3771
Number of pages4
Issue number12
Publication statusPublished - Dec 2009


  • Biostatistics
  • Brain imaging
  • Cerebral infarct
  • Clinical trial design
  • Diagnostic methods
  • Magnetic resonance imaging
  • Outcomes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing


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