Interstitial and large chromosome 1p deletion occurs in localized and disseminated neuroblastomas and predicts an unfavourable outcome

Achille Iolascon, Crocifissa Lo Cunsolo, Lucia Giordani, Roberto Cusano, Katia Mazzocco, Martina Boumgartner, Paola Ghisellini, Maria Felicia Faienza, Luca Boni, Bruno De Bernardi, Massimo Conte, Giovanni Romeo, Gian Paolo Tonini

Research output: Contribution to journalArticle

Abstract

We studied chromosome 1p loss of heterozygosity (1p-LOH) in 53 neuroblastomas (NBs) using 15 (CA)n repeat loci, which covered a region of 90 cM. We also assessed chromosome 1p36 deletion by fluorescence in situ hybridization (FISH) on interphase nuclei. 1p-LOH was found in 19 (36%, 95% confidence interval (CI) 23-50%) NBs. We detected interstitial and large deletion in both localized and disseminated tumours and in one tumour of a patient at stage 4S. Allelic loss was frequently observed in 1p36 and 1p32 regions. In patients older than 1 year of age (53 versus 13%, P <0.002) we detected significant chromosome 1p deletion and it was associated with MYCN amplification (P = 0.001). Overall survival (OS) analysis showed that 1p-LOH is predictive of a poor outcome (odds ratio 16.5, 95% CI 5.4-50.9%); therefore, 1p-LOH should be regarded as an additional tumour progression marker in neuroblastoma.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalCancer Letters
Volume130
Issue number1-2
DOIs
Publication statusPublished - Aug 14 1998

Keywords

  • Chromosome 1
  • Loss of heterozygosity
  • Microsatellite
  • MYCN amplification
  • Neuroblastoma

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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  • Cite this

    Iolascon, A., Lo Cunsolo, C., Giordani, L., Cusano, R., Mazzocco, K., Boumgartner, M., Ghisellini, P., Faienza, M. F., Boni, L., De Bernardi, B., Conte, M., Romeo, G., & Tonini, G. P. (1998). Interstitial and large chromosome 1p deletion occurs in localized and disseminated neuroblastomas and predicts an unfavourable outcome. Cancer Letters, 130(1-2), 83-92. https://doi.org/10.1016/S0304-3835(98)00122-0