Interstitial cystitis and infectious agents.

D. Fioriti, M. Penta, M. Mischitelli, A. M. Degener, A. Pierangeli, V. Gentile, R. Nicosia, C. Gallinelli, F. Chiarini, V. Pietropaolo

Research output: Contribution to journalArticle

Abstract

Interstitial cystitis (IC) is a syndrome consisting of severe refractory bladder symptoms of unknown etiology. The disease tends to affect Caucasian women with a mean age of 40 years, with 25% of patients under the age of 30. Few population based epidemiological studies of IC have been performed. We analyzed a case of interstitial cystitis in a 42-year-old non-smoker woman. In two biopsy samples the presence of viral DNA of human polyomavirus BK (BKV), human herpes virus type 1 and type 2 (HHV- 1 and HHV-2), adenovirus, human papillomavirus (HPV) and bacterial DNA (Chlamydia trachomatis and Mycoplasma genitalium) were evaluated by means of polymerase chain reaction (PCR). Both samples resulted positive only for BKV and HPV DNA. HPV genotyping revealed the presence of HPV-66 that is associated with a high risk of cancer development. Thus the finding of a viral co-infection could support the hypothesis of the multi-factorial origin of this pathology.

Original languageEnglish
Pages (from-to)799-804
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Volume18
Issue number4
Publication statusPublished - Oct 2005

ASJC Scopus subject areas

  • Pharmacology

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    Fioriti, D., Penta, M., Mischitelli, M., Degener, A. M., Pierangeli, A., Gentile, V., Nicosia, R., Gallinelli, C., Chiarini, F., & Pietropaolo, V. (2005). Interstitial cystitis and infectious agents. International Journal of Immunopathology and Pharmacology, 18(4), 799-804.