TY - JOUR
T1 - Terapie percutanee interstiziali dei tumori primitivi e secondari del fegato
AU - Torzilli, G.
AU - Livraghi, T.
AU - Olivari, N.
PY - 1999/3
Y1 - 1999/3
N2 - Multiple percutaneous interstitial systems to induce intrahepatic tumor necrosis are classifiable in two major groups: those using chemical agents (ethanol and acetic acid) and those adopting thermal effects (hot saline, radiofrequency, User and microwave). Indication, technique and results of percutaneous ethanol injection (PEI) are considered. In the case of single hepatocellular carcinoma (HCC), <5 cm and associated with cirrhosis Child diss A long-term results of PEI are comparable with those of best surgical series with 5-years survival which range from 47 to 51 %. No mortality and recurrence rates similar to those of surgical cases make PEI as an alternative to surgical resection although the difficulties in comparing retrospectively the different experiences do not enable definitive conclusions. In the case of liver metastases from colorectal cancer or endocrine tumors, which seem more sensitive to locoregional therapies, complete response rates are not adequate yet being 86%, 26%, 11% and 0% respectively in the case of <2 cm, 2-3 cm, 3-4 cm and > 4 cm lesions and moreover no definitive data are available about long-term prognosis. Waiting for j'urther validation about the encouraging data obtained with the other interstitial methods and in particular with radiofrequenty (RE) and Ltser interstitial photocoaguLition (ELI), PEI is a valid alternative to surgery for selected HCC patients and is a good palliation in cases with not resectable liver metastases w hich are anyway suitable for locoregional treatments.
AB - Multiple percutaneous interstitial systems to induce intrahepatic tumor necrosis are classifiable in two major groups: those using chemical agents (ethanol and acetic acid) and those adopting thermal effects (hot saline, radiofrequency, User and microwave). Indication, technique and results of percutaneous ethanol injection (PEI) are considered. In the case of single hepatocellular carcinoma (HCC), <5 cm and associated with cirrhosis Child diss A long-term results of PEI are comparable with those of best surgical series with 5-years survival which range from 47 to 51 %. No mortality and recurrence rates similar to those of surgical cases make PEI as an alternative to surgical resection although the difficulties in comparing retrospectively the different experiences do not enable definitive conclusions. In the case of liver metastases from colorectal cancer or endocrine tumors, which seem more sensitive to locoregional therapies, complete response rates are not adequate yet being 86%, 26%, 11% and 0% respectively in the case of <2 cm, 2-3 cm, 3-4 cm and > 4 cm lesions and moreover no definitive data are available about long-term prognosis. Waiting for j'urther validation about the encouraging data obtained with the other interstitial methods and in particular with radiofrequenty (RE) and Ltser interstitial photocoaguLition (ELI), PEI is a valid alternative to surgery for selected HCC patients and is a good palliation in cases with not resectable liver metastases w hich are anyway suitable for locoregional treatments.
KW - Alcohol injection
KW - Hepatocellular carcinoma
KW - Interstitial therapy
KW - Laser induced phtocoagulation
KW - Liver metastases
KW - Liver neoplasms
KW - Microwave
KW - Radiofrequency
UR - http://www.scopus.com/inward/record.url?scp=0033087676&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033087676&partnerID=8YFLogxK
M3 - Articolo
C2 - 10434450
AN - SCOPUS:0033087676
VL - 70
SP - 185
EP - 194
JO - Annali Italiani di Chirurgia
JF - Annali Italiani di Chirurgia
SN - 0003-469X
IS - 2
ER -